User:Testem

My interests include pharmacology, chemical engineering, chemistry and drug use.

I have a keen interest in indexing information to allow interested parties to quickly learn more about a subject while also allowing experts to expand their understanding and support their claims. This page is a collection of some interesting facts I've pulled out over the years, mostly for my own use.

Created pages
I have created a number of pages, particularly regarding reagent tests for drug identification and TLC development.
 * Dille–Koppanyi reagent
 * Ehrlich's reagent
 * Froehde reagent
 * Mecke reagent
 * Mandelin reagent
 * Simon's reagent
 * Duquenois-Levine reagent
 * 6-(2-Aminopropyl)indole
 * Zwikker reagent
 * 5-MAPB
 * Vacuum bazooka
 * Bk-2C-B
 * Zimmermann reagent
 * 4-anilino-N-phenethylpiperidine (ANPP)

Developed
I created most of the content for 5-(2-Aminopropyl)indole and have contributed considerably to the entries for blood substitutes, tert-Amyl alcohol, methoxetamine, alcohol toxicity, oxygen scavengers, 2C-B, emylcamate, aMT and desoxypipradrol.

I have thoroughly overhauled a number of articles on air separation techniques including gas separation, oxygen concentrators, pressure swing adsorption, membrane gas separation and portable oxygen concentrators.

Van urk reagent
Similar to the the wasicky reagent. It may also be referred to as the Para-Dimethylaminobenzaldehyde test, after the main reagent.

Interesting drugs

 * Zipeprol is a centrally acting cough suppressant developed in France in the 1970s. Zipeprol acts as a local anaesthetic and has mucolytic, antihistamine and anticholinergic properties. . It has been misused in Korea, mainly for the hallucinations it produces. Such use has become an issue due to the seizures and various neurological side effects it causes at high dosages.
 * Nitromethaqualone is more 10x potent than methaqualone could replacing the nitro with another EWG retain the potency while losing the toxicity? Cloroqualone is less potent than methaqualone, so what would an EDG like -OR do in place of chlorine?Discussion:
 * MTEP and MPEP. MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective, antidepressant and anxiolytic effects but with either similar or higher efficacy depending on the test used.
 * 2-Phenyl-3,6-dimethylmorpholine "wqs one of the battery of compounds fed to rats during my short bout of academia (I'll try and find my notes, but it's from 20-odd years ago & the spare room is full of crap that needs to be sorted); the reason it stuck in my mind, other than not being a controlled substance, is that the phenmetrazine series are quite a simple synth from phenylpropanolamine (no synth details for obvious reasons). The 3,5 dimethyl compound behaves more like an N-isopropyl substituted sympathetic agent (more peripheral effects such as pounding heart, dry mouth, sweating etc) and is possibly stearically hindered about the amine function due to increased rigidity conferred by the morpholine ring (expressed as only having a fraction of the locomotor stimulant/appetite supressant activity of the 3,6 or parent phenmetrazine)"
 * Etoxadrol is a dissociative not covered by the UK's catch all clause
 * GYKI-52895 A benzo-1,2-diazepine which acts as a DRI. An MDMA moeity can be seen.
 * Abecarnil is a novel anxiolytic based on beta-Carboline

Vasodilation caused by ibuprofen
Ibuprofen has been shown to dilate arteries in rats with coronary vasodilation, equal to that caused by hypoxia at 140 µg/mL. Typical human dosages of 400mg result in a concentration of 20-60 µg/mL. This indicates that ibuprofen is not a meaningful vasodilator.