User:The-GOAT-of-GOATs/Multiple sclerosis/Bibliography

You will be compiling your bibliography and creating an outline of the changes you will make in this sandbox.

Outline of proposed changes
Workplan


 * Throughout article, update citations with more up-to-date references


 * Intro paragraphs: Finish by 12/3
 * change degenerative to autoimmune disease (change link as well) in first sentence for more specificity
 * Add in brief description of progressive MS in first paragraph since it describes relapsing-remitting MS
 * In second paragraph, edit sentence on proposed causes to refer to later section
 * In third paragraph, edit sentence on treatment to reflect acute flare management, disease-modifying therapy for long-term relapse prevention, and patient-centered symptom management.
 * In third paragraph, remove sentence on alternative treatments altogether since they have not been proven to be efficacious: can touch on them later in treatment section


 * Signs & Symptoms section: Finish by 12/3
 * Clarify first paragraph's description of classic MS presenting symptoms
 * Clarify psychiatric symptoms of MS
 * Remove sentence on CIS: unsupported claim
 * Start third paragraph with percentages o most common symptoms using updated citation
 * Edit section on disease course to refer to MS types later in article
 * Causes section: Finish by 12/3
 * Intro paragraph/sentence: clarify that leading hypothesis is autoimmune dysregulation
 * Add in section detailing autoimmunity of MS
 * Infectious agents subsection: remove first sentence as it is not helpful, rest of this subsection looks good
 * Genetics subsection: edit first paragraph's last section to reflect what ethnic groups are disproportionally impacted, edit second paragraph to clarify that only the HLA-DR15 allele is associated with higher risk of MS development
 * Geography: include role of vitamin D & latitude in explanation of increasing MS risk as you move away from the equator
 * Other: include the following risk factors: obesity, diet & gut microbiome, comorbidities
 * Pathophysiology section: Finish by 12/10
 * Remove sentence on cholesterol crystals: while may be true & supported by research, is not particularly relevant to the pathophysiology of MS as we currently understand it
 * Add "immune dysregulation" subsection to explain current thoughts of the development of autoimmunity that leads to MS
 * Diagnosis section: Finish by 12/10
 * Overall accurate & concise, will add in paragraph clarifying what the McDonald Criteria are, what DIS & DIT are and what can be done to prove them
 * Remove sentence on brain atrophy: this finding is non-specific to MS
 * Add paragraph on studies that can support diagnosis of MS
 * Differential Diagnosis section is overall accurate & concise
 * Types & Variants: Finish by 12/10
 * Overall accurate & concise, will add paragraph detailing radiologically isolated syndrome (RIS)
 * Management: Finish by 12/15
 * Acute flare management: overall accurate, clarify that IVIG & plasmapheresis can be use concurrently with steroids
 * Clarify indications & side effects of most commonly used disease-modifying drugs