User:TheIguana/sandbox

Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene.

Function
The Dmrt1 gene is believed to be part of the sex-determination pathway in invertebrates, mammals and birds  Dmrt1 contains a zinc finger-like DNA-binding motif (DM domain) that is also present in the sex-determination genes doublesex of flies and mab-3 of nematodes. The DNA-binding motif is an ancient conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes, and is found to be the key sex-determining factor in chickens. This gene exhibits a gonad-specific and sexually dimorphic expression pattern, just like the related doublesex gene in fruit flies. Defective testicular development and XY feminization occur when this gene is hemizygous.