User:Thegastermaster/sandbox

Article Evaluation

Stub: Ferroptosis

https://en.wikipedia.org/wiki/Ferroptosis

Secondary Review
This is a well-written article. Diagrams were appropriate and easy-to-follow. Some sentences are slightly wordy and could be simplified. Some sections, like the 'Role of Ferroptosis in Cancer Treatment' section, could use more sources. There is one citation in that section; if that's what the section is based off of, the other information in the section could use that same citation, just for clarity. Kyle Smith (talk) 20:58, 13 May 2018 (UTC)

Possible Articles
https://en.wikipedia.org/wiki/CapZ

The CapZ article could really use an introduction. It goes straight into function and could be jarring for those who are unfamiliar to cell biology.

https://en.wikipedia.org/wiki/Ferroptosis

It could use some shortened sentences and a few citations, but other than that, it is a solid article.

Finalized Topic
https://en.wikipedia.org/wiki/Ferroptosis

I plan to simplify two sentences in the introduction of the article. I also plan to add another source citation to the Role of Ferroptosis in Cancer Treatment section.

Potential Bibliography:


 * Lachaier, Emma, Christophe Louandre, Corinne Godin, Zuzana Saidak, Maxime Baert, Momar Diouf, Bruno Chauffert, and Antoine Galmiche. “Sorafenib Induces Ferroptosis in Human Cancer Cell Lines Originating from Different Solid Tumors.” Anticancer Research 34, no. 11 (November 1, 2014): 6417–22.
 * Ma, Shumei, Rebecca F. Dielschneider, Elizabeth S. Henson, Wenyan Xiao, Tricia R. Choquette, Anna R. Blankstein, Yongqiang Chen, and Spencer B. Gibson. “Ferroptosis and Autophagy Induced Cell Death Occur Independently after Siramesine and Lapatinib Treatment in Breast Cancer Cells.” PLOS ONE 12, no. 8 (August 21, 2017): e0182921. https://doi.org/10.1371/journal.pone.0182921.
 * Shen, Zheyu, Jibin Song, Bryant C. Yung, Zijian Zhou, Aiguo Wu, and Xiaoyuan Chen. “Emerging Strategies of Cancer Therapy Based on Ferroptosis.” Advanced Materials (Deerfield Beach, Fla.) 30, no. 12 (March 2018): e1704007. https://doi.org/10.1002/adma.201704007.

Article Draft
Ferroptosis is an iron-dependent form of programmed cell death. Improper function of glutathione-dependent antioxidant defenses leads to overproliferation of lipid peroxides in cells. These lipid peroxides are oxidized by free radicals and lead the cell to a controlled death. This distinct regulatory pathway also plays a role in tumor development and cancer treatment.

Article Improvement: This article isn't exactly lacking in information, yet more information could be added to the Role of Ferroptosis in Cancer Treatment in the form of other sources.

Original Sentences: "The role ferroptosis plays in the human body by being induced revolves around the regulation of growth and proliferation of some types of tumor cells. While it can contribute to the human body with positive effects, it can be detrimental in outcomes as well. The main negative effects it may have on the body are the disruption of metabolic pathways, or disruption to the homeostasis of the body."

Proposed Revision: "Ferroptosis activation plays a regulatory role on growth of tumor cells in the human body. However, the positive effects of ferroptosis could be potentially neutralized by its disruption of metabolic pathways and disruption of homeostasis in the human body." Proposed Addition to the end of 'Role of Ferroptosis in Cancer Treatment' Section: "Breast cancer cells have exhibited vulnerability to ferroptosis via a combination of siramesine and lapatinib.  These cells also exhibited an autophagic cycle independent of ferroptotic activity, indicating that the two different forms of cell death could be controlled to activate at specific times following treatment.