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Missouri
From 2012-2016, Missouri was ranked eighth in cotton production in the United States with the average production value of $191,004,400. Missouri soil allows for the growth of upland cotton with the average bale weighing approximately five hundred pounds. The cottonseed from Missouri cotton production is used as livestock feed. According to the University of Missouri, cotton production per acreage in this state peaked in the 1953 and decreased to its lowest point in 1967. In terms of yield, Missouri yielded a record low of 281 pounds/acre in 1957 and a record high of 1,097 pounds/acre in 2015.

The top four upland cotton producing counties in Missouri are New Madrid (197,000 bales in 2016), Dunklin (171,200 bales in 2016), Stoddard (110,000 bales in 2016), and Pemiscot (72,000 bales in 2016). Other combined counties in Missouri produced 15,800 bales in 2016. In 2017, total Missouri cottonseed sales were 179,000 tons. Missouri upland cotton production in 2017 was valued at $261,348,000 with 750,000,480 pound bales produced in that year. According to the United States Department of Agriculture, upland cotton in Missouri was valued at 0.751 $ / pound in 2017. Cottonseed production was less valuable that year in terms of dollar value, with a total production being 255,000 tons valued at $39,824,000 ($152/ton).

While cotton fibers are often used for textile production, cottonseed is a valuable feedstuff supplement for livestock. Cottonseed kernels are a more cost effective source of both fiber and protein. Cottonseed as supplement is marketed primarily towards agricultural sectors that feed dairy cows. Some feedlots use corn to supplement the forage diets of cows; high starch diets, such as those in corn supplemented diets, can lead to liver damage in cows. Cottonseed is considered a safer alternative to corn supplemented diets due to its low starch content. Cottonseed as livestock feed must also be monitored for safety since the foodstuff is high in energy/fat and too much fat content in a cow's diet can disrupt its ability to digest fiber, leading to other complications.