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Six Sigma for ROI (SSROI) is a practice for increasing ROI through Six Sigma by applying Six Sigma best practices.

Six Sigma for ROI deals with current limitation of Return on Investment (ROI) measurement, Six Sigma, and the Project Management Office (PMO). Six Sigma benefits are well known, but end due to project entropy. ROI measurement limitations are related to intangibles. PMO business value limitations are related to intangible administrative benefits. Six Sigma for ROI creates PMO accountability to ROI by allowing executives to promote the value of their portfolio by aligning corporate resources to the right initiatives in their corporate portfolio.