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Glucokinase (GK) is an enzyme that helps in the glycolytic pathway just as hexokinase by phosphorylating glucose into glucose 6-phosphate. It is found mainly in pancreatic β cells and liver where glycolysis cause glucose -induced insulin secretion. Glucokinase have a single allosteric site where the glucose-regulating protein (GKRP) binds in the nucleus of the cell in its inactive form, when there is low concentration of glucose present in the cell. However, when the glucose concentration of the cell increases the glucokinase- GKRP complex breaks apart and GK proceeds to the cytoplasm where it then phosphorylates glucose. Glucose when abundant in cells acts as an enzyme activator for glucokinase. Glucokinase activation in the β cells and liver cells results in the uptake of glucose and production of glycogen. This activation in the β cells leads to insulin secretion, promoting glucose uptake storing it as glycogen in the muscles.