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Hashem El-Serag is a Palestinian-American doctor and medical researcher best known for his groundbreaking research in Hepatocellular carcinoma (HCC) and the hepatitis C virus.

El-Serag was born in 1966 in Libya to Palestinian parents from the Gaza Strip. He received his M.D. from Al-Arab Medical University in Benghazi, Libya. He then moved to the United States, where he performed his residency in internal medicine at Yale University Greenwich Hospital (Connecticut) and received a gastroenterology fellowship at the University of New Mexico in Albuquerque, before earning his Master of Public Health from the University of New Mexico.

Nearly all of the research on Hepatocellular carcinoma in the United States can be attributed to El-Serag, who has published over 120 scholarly papers on the subject, and received the GlaxoWellcome Digestive Health Foundation Award for Health Care Advancement in 1997, the American Gastroenterological Association's Young Clinical Investigator Award in 2003, and the American Gastroenterological Association's Masters Award in Clinical Research in 2005 for his work. El-Serag has also become a leading expert on chronic liver disease, gastroesophageal reflux disease and genetic epidemiology.

He is currently Chief of Gastroenterology and Hepatology at Baylor College of Medicine, and the Chief of Clinical Epidemiology and Outcomes Division at Houston VA Medical Center in Houston, Texas. In addition, he is the Editor-in-chief of "Clinical Gastroenterology and Hepatology".