User:Tridwoxi/Draft/Transcription elongation factor

In cellular biology, eukaryotic transcription is the production of a primary transcript from DNA by RNA polymerases. Regulation of transcription elongation by elongation factors is necessary to continue transcription and reduce the probability of dissociation of RNA polymerase II from the transcribed gene. RNA polymerase II most frequently pauses at promoter-proximal regions, where transcription elongation factors such as P-TEFb and its associated complexes, SII, elongin, ELL, NELF, DSIF, and PAF1 may modulate its activity.

Early detection of RNA polymerase II pausing at a promoter-proximal region between -12 and + 65 nucleotides was seen in the Hsp70 gene in cells not in heat shock, thus possibly serving to regulate transcription.