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Autonomic Technologies, Inc. is a medical device company that develops medical devices to work with the autonomic nervous system. The company is best known or its ATI Neurostimulator System (marketed under Pulsante Microstimulator System in Europe) device used to treat cluster headaches. The device was named as one of the best medical innovations for 2013 by the Cleveland Clinic.

History
Autonomic Technologies was founded in 2007 and is based in Redwood City, California. The company was born at the Cleveland Clinic with the invention of a device used to treat headaches. The device was originally part of the clinic's research into deep-brain stimulation to treat Parkinson's disease. It was discovered based on the workd of Dr. Ali Rezai of the Clevelend Clinic, who became a member of the board of directors with the company.

Initially funding for the company came from Kleiner Perkins Caufield & Byers and Cleveland Clinic Innovations. Autonomic Technologies raised $20 million in a Series B round of funding in 2009, led by InterWest Partners. It closed a Series C round of funding in 2011 in the amount of $38 million, led by Edmond de Rothschild Investment Partners. The company received $38 million in Series D funding in May of 2015. The round was led by Edmond de Rothschild Investment Partners with participation from Forbion Capital Partners and existing investors Keliner Perkins Cufield and Byers, InterWest Partners, Novartis Venture Fund, Aberdare Ventures, and the Cleveland Clinic. The round brought Autonomic's funding to $93 million.

Autonomic Technologies has won numerous awards, many of which came in 2013. That year, it was listed as the Best of What's New by Popular Science, a Red Herring Top 100 North American Tech Startup, and was a finalist for a Medical Design Excellence Award. In 2013 its medical device was named as one of the best medical innovations by the Cleveland Clinic. Prior to that time it had received a Fierce 15 recognition from FierceMedicalDevices and was listed as a top 50 company to watch by MD&DI.

Technology
Autonomic Technologies is best known for its ATI Neurostimulator System (marketed under Pulsante Microstimulator System in Europe) device, used to treat cluster headaches. It is used by implanting a device in the area of the cheekbone at the sphenopalatine ganglion, a nerve bundle involved in the mechanism of cluster headaches. Patients can then use an external device to control pain when they are affected by a cluster headache. The device is available in Europe and in clinical trials in the United States.

The first U.S. implant took place in August 2014. The device, described as the size of an almond, was implanted in a patient at The Ohio State University Wexner Medical Center. It was the first in a double blind U.S. clinical trial scheduled to take place with 120 test subjects during a one year period.