User:UltraStableTetraLoop/TRAF interacting protein

Role In Mitotic DNA Synthesis (MiDAS)
MiDAS is thought to be a DNA repair mechanism to salvage DNA that has not finished replication during S phase, which may be due to DNA replication stress (RS). Intrinsic sources of RS include transcription-replication conflicts and “difficult-to-replicate’’ regions. Extrinsic RS includes exposure to genotoxic agents, depletion of dNTPs, and premature S phase activity which can occur in precancerous cells after oncogene activation. Some MiDAS pathways require the TRAIP protein to disassemble the replication complex at the stalled replication fork in cases where RS causes the fork to stall during replication.