User:Umadewa7/sandbox

Fuel generating molecules such as amino acids and carbohydrates enter the Krebs Cycle as acetyl coenzyme A and oxidize in the cycle. An enzyme called Pyruvate Dehydrogenase Complex (PDC) acts as a catalyst during oxidative decarboxylation of pyruvate and thereby results in synthesis of acetyl-CoA, Carbon Dioxide and NADH. It also oxidizes glucose by forming a linkage between the glycolytic pathway and oxidative pathway of Krebs Cycle. In eukaryotes, this enzyme complex regulates pyruvate metabolism and ensures homeostasis of glucose during the absorptive and post-absorptive state metabolism. The Krebs Cycle occurs inside mitochondria so the pyruvate that was generated during glycolysis in the cytosol needs to enter the mitochondrial membrane