User:Umordi/sandbox

Naltrexone Potential Edits:

-MoA + frequency of dosing basically expanding on why compliance is an issue + how long it takes to work (Uche)

Naltrexone is an opioid receptor antagonist. It works by blocking the physiological effects of opioids and thereby preventing euphoria from opioid use. Non-compliance with naltrexone is a concern for oral formulations because of its daily dosing [63]. The alternative intramuscular injection has better patient compliance due to its monthly dosing. Naltrexone monthly IM injections (Vivitrol®) received FDA approval in 2010 for indication of use in patients with opioid dependence but not current opioid users [64].
 * 1) https://www.ncbi.nlm.nih.gov/books/NBK64042/


 * 1) http://www.annualreviews.org.ucsf.idm.oclc.org/doi/pdf/10.1146/annurev-pharmtox-010617-052534
 * 2) https://www.vivitrol.com
 * 3) https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021897s015lbl.pdf