User:Utkj2022/Epigenetics of depression

Lead
Start with what depression is defined as, possibly using DSM definition as this is likely what many researchers are using to frame it.

Possibly define epigenetics as neuroscience defines it, such that the rest of the article is consistent with these two definitions (possibly using the Sweatt chapter "An Overview of the Molecular Basis of Epigenetics").

A list of references for the following points are here.


 * environmental stressors preceding depression and its mechanisms
 * papers that deal with the findings of childhood environmental stressors that lead to epigenetic changes which shift the propensity that an individual will experience depression, as the shift in understanding of the link between depression and environmental stressors lies in epigenetics
 * risk for major depression as environmental and genetic (good transition between environmentally gained epigenetic mechanisms to endogenous propensity for major depression)
 * more broad view of the pathogenesis of depression being linked to epigenetic mechanisms
 * specifies miRNA and DNA methylation, as well as histone markers
 * use of rats to look at DNA methylation (the "methylome") in high-responder vs. low responder rats (finding a link between methylation and high/low behavior)
 * Postpartum depression
 * changes to central nervous system due to hormones, changes in expression of genes (epigenetic mechanisms) as an underpinning for postpartum depression

''' This is a very important topic, and you clearly put a lot of time into doing background research and finding good reviews. '''

''' There already appears to be a rather extensive article on epigenetics and depression https://en.wikipedia.org/wiki/Epigenetics_of_depression, and it looks like it has been updated pretty recently. How do you plan to make substantial contributions to the existing wikipedia page? '''

''' Also, I think it's fine to use some slightly older review articles. They don't all have to be quite so recent since reviews tend not to be written too frequently as they have to wait for more primary research to be conducted. '''

''' --Trevor '''