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PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics. It integrates a pharmacokinetic and a pharmacodynamic model component into one set of mathematical expressions that allows the description of the time course of effect intensity in response to administration of a drug dose. PK/PD modeling is related to the field of pharmacometrics.

La modellazione PK/PD (modellazione farmacocinetica/farmacodinamica) (abbreviata anche come modellazione PKPD o PK-PD ) è una tecnica che combina le due discipline farmacologiche classiche della farmacocinetica e della farmacodinamica. Le componenti dei modelli farmacocinetico e farmacodinamico vengono integrate in un insieme di espressioni matematiche che consente la descrizione dell'andamento temporale dell'intensità dell'effetto in risposta alla somministrazione di una dose di farmaco. La modellazione PK/PD è correlata al campo della farmacometria.

A variety of PK/PD modeling approaches exist to describe exposure-response relationships. PK/PD relationships can be described by simple equations such as linear model, Emax model or sigmoid Emax model. However, if a delay is observed between the drug administration and the drug effect, a temporal dissociation needs to be taken into account and more complex models exist: PK/PD modeling has its importance at each step of the drug development and it has shown its usefulness in many diseases. The Food and Drug Administration also provides guidances for Industry to recommend how exposure-response studies should be performed.
 * Direct vs Indirect link PK/PD models
 * Direct vs Indirect response PK/PD models
 * Time variant vs time invariant
 * Cell lifespan models
 * Complex response models