User:Vanshika Patel/sandbox

Latrunculin link

The latrunculins are a family of natural products and toxins produced by certain sponges, including genus Latrunculia and Negombata, whence the name is derived. It binds actin monomers near the nucleotide binding cleft with 1:1 stoichiometry and prevents them from polymerizing. Administered in vivo, this effect results in disruption of the actin filaments of the cytoskeleton, and allows visualization of the corresponding changes made to the cellular processes. This property is similar to that of cytochalasin, but has a narrow effective concentration range. Latrunculin has been used to great effect in the discovery of cadherin distribution regulation. Latrunculin A, a type of the toxin, was found to be able to make reversible morphological changes to mammalian cells by disrupting the actin network

Things adding

Latunculin A Target and functions:

Target Gelsolin- Latrunculin A causes end- blocking; this protein binds to the barbed sides of the actin filaments which accelerates nucleation. This calcium- regulated protein also plays a role in assembly and disassembly of cilia which plays a crucial role in handedness.

Latunculin B

·        Is everything in the article relevant to the article topic? Is there anything that distracted you?

According to me everything in the article is relevant to its topic and there is nothing that distrateed me when i was reviewing it.

·        Is the article neutral? Are there any claims, or frames, that appear heavily biased toward a particular position?

"Latrunculin has been used to great effect in the discovery of cadherin distribution regulation" this claim seems biased to me as there are no references supporting it thus it seems that this was biased to a particluar position.

·        Are there viewpoints that are over represented, or underrepresented?

No there are no viewpoints in my opinion that are either over represented or underrepresented.

·        Check a few citations. Do the links work? Does the source support the claims in the article?

The articles are too old therefore it is hard to get back to the exact article using the doi.

·        Is each fact referenced with an appropriate, reliable reference? Where does the information come from? Are these neutral sources? If biased, is that bias noted?

I am not able to check this because the article's cited are old and therefore hard to get to.

·        Is any information out of date? Is anything missing that could be added?

Yeah, experiments where the toxic is used could be added.

·        Check out the Talk page of the article. What kinds of conversations, if any, are going on behind the scenes about how to represent this topic?

The talk page is empty.

·        How is the article rated? Is it a part of any WikiProjects?

The article is rated as a stub;

This article is within the scope of the WikiProject Molecular and Cell Biology,Wiki Education Foundation-supported course assignment and WikiProject Chemicals.