User:Vekramaditya/sandbox

Standardization of Ayurvedic Drugs NOT Easy

 * Multi component systems
 * Variations in processing conditions
 * Methods of production vary
 * Variety of chemical changes possible
 * Classical methods also vary
 * Classical & industrial method differ1
 * Not a single component treatment system

Problems of Drug Standardization

 * Raw materials differ significantly
 * Proportions of raw drug also vary
 * Quality of raw drugs varies
 * Pyrolitic changes are possible
 * Hydrolytic changes are possible
 * Changes during storage possible
 * Loss of volatiles possible

Problems on Quality of Raw Drugs

 * Maturity of the raw drugs
 * Harvesting seasons & conditions
 * Storage, handling, transportation
 * Pre and post harvest handling
 * Adulterant and substituents mixed
 * Spoilage during the above processing
 * Availability of the raw drugs

Possible Changes in Drugs

 * Chemical changes during heating
 * Hydrolytic changes on storage & heating
 * Changes due to other drug components
 * Changes due to pH variations
 * Artefact formation on processing & storage
 * Effect of preservatives on components
 * Changes due to micro-organisms

Present Trends and Their Impact

 * Technological innovations
 * Variations in heating
 * Use of concentrates & extracts
 * Storage and Preservatives
 * Packing, transportations & storage
 * Making the concentrates of drugs
 * High level ‘flavor’ additions

Possible Options on Standardization

 * Standardization using physical properties
 * Standardization of classical products
 * Standardization by tracing active principles
 * Comparison of raw /product components
 * Chemical and instrumental analyses
 * Chromatographic finger printing

Possible Options & Pathways

 * Standardization of classical products &
 * Standardization of industrial products
 * Clinical study methods
 * Tracing active principles in raw and processed drugs & products
 * Making and referring the  data  on quality of both classical and industrial products

Analyses of Ayurvedic Products

 * Color of product /filtrate /residue, Nature, Viscosity, Odor, Taste, Solubility, Residue content, pH, Ash content, Acid solubles, Acidity, Volatiles, Solid content, Moisture /water content, Alcohol content, Nature & content of non volatiles, Lipid /protein /inorganic /carbohydrate contents, Essential /fixed oil contents ……

Analyses of Ayurvedic Drugs

 * Gas Chromatography for Volatiles.  HPLC  for  non volatiles.  TLC and HPTLC  for  Non volatiles  etc  can be used for the products obtained  by distillation  and /or extraction using various solvents  and solvent mixtures  at different conditions

Chromatographic Finger Printing

 * Classical products as reference
 * Standard  component as reference
 * Quality specified as standard reference
 * Guidance specified as  reference
 * Self imposed guidance for reference
 * Finger printing observation as reference