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Causes[edit source | editbeta]
Nobel Laureate Charles Richet discovered that proteins injected into animals caused them to develop sensitization to those proteins. Subsequent exposure to those proteins would result in anaphylaxis - a term he coined.

The detailed mechanism of such allergy development is described here.

Today, it is common to induce food allergy in laboratory mice by injecting them with food proteins along with alum as an adjuvant.Relative immunogenicity of commonly allergenic foods versus rarely allergenic and nonallergenic foods in mice.Birmingham N., Thanesvorakul S., Gangur V. Relative immunogenicity of commonly allergenic food versus rarely allergenic and non-allergenic foods in mice. J. Food Prot. 2002;65:1988–1991.http://www.ncbi.nlm.nih.gov/pubmed/12495022

Multiple routes of food protein administration have been shown to cause food allergies in humans.

Tick bites can cause alpha-gal to be injected. Alpha-gal is a protein found in red meat. The result is tick bite victims develop red meat allergy. Commins SP, Platts-Mills TA. Allergenicity of carbohydrates and their role in anaphylactic events. Curr Allergy Asthma Rep. 2010;10:29–33. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057034/

Stomach acids degrade food proteins. Stomach acid reducing medications such as proton pump inhibitors (PPI) affect protein degradation. When stomach acid is reduced, intact food proteins are absorbed into the blood stream resulting in the development food allergies.Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, Riemer AB, Ankersmit HJ, Scheiner O, Boltz-Nitulescu G, Jensen-Jarolim E. Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients. FASEB J. 2005;19:656–658. [PubMed]http://www.ncbi.nlm.nih.gov/pubmed/15671152

Vaccines such as DTaP contain food proteins such as gelatin. Gelatin containing DTaP has been shown to cause gelatin allergy. http://www.ncbi.nlm.nih.gov/pubmed/9949325

http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf