User:Vreddy9/sandbox

Section: Prevention

Naloxone Naloxone is a mu-opioid receptor antagonist that is used for emergency reversal of opioid overdose. It can be administered by many routes (intramuscular, intravenous, subcutaneous, intranasal, and inhalation) and acts very quickly by kicking off and replacing opioids from the opioid receptors. Since this is a life-saving medication, many states have implemented Standing Orders for law enforcement to carry and administer Naloxone as needed. In addition, naloxone could be used to challenge a patient's opioid abstinence status prior to starting a medication such as naltrexone, which is used in the management of opioid addiction.

1. http://www.crlonline.com/lco/action/doc/retrieve/docid/patch_f/7338#f_pharmacology-and-pharmacokinetics 2. https://www.fda.gov/downloads/Drugs/NewsEvents/UCM454810.pdf 3. http://naloxoneinfo.org/case-studies/standing-orders 4. Schuckit, Marc A. Treatment of Opioid-Use Disorders — NEJM. New England Journal of Medicine, 28 July 2016, www.nejm.org/doi/full/10.1056/NEJMra1604339#t=article. http://www.nejm.org/doi/full/10.1056/NEJMra1604339#t=article

Vreddy9 (talk) 20:31, 24 October 2017 (UTC)

Naloxone is a competitive antagonist of the μ-opioid receptor that is used for the emergency treatment of an opioid overdose. It can be administered by many routes (e.g., intramuscular, intravenous, subcutaneous, intranasal, and inhalation) and acts very quickly by displacing opioids from opioid receptors and preventing activation of these receptors by opioids. Since this is a life-saving medication, many states have implemented standing orders for law enforcement to carry and administer naloxone as needed. In addition, naloxone could be used to challenge a patient's opioid abstinence status prior to starting a medication such as naltrexone, which is used in the management of opioid addiction. Vreddy9 (talk) 08:46, 6 November 2017 (UTC)