User:WKB321/Maleimide/Alexniy Peer Review

Maleimide by WKB321--Peer review by Alexniy

In the lead, the chemical compound discussed in the article has the class of compound classified, functional groups/organic groups it interacts with, and a notable use of it in human biochemistry. This is a great lead that was decided not to be changed by the student, which I think was satisfactory, since the information provided give a decent overview of the remaining article.

The sections, Organic chemistry and Natural maleimides, did not appear to be edited by the student. This contains a decent, simple overview of the corresponding sections, including Michael additions and Diels-Alder reaction due to the compound's ability to perform these additions in addition to a short discussion of microorganisms that contain this compound. These appear to be at the forefront of the discussion of the compound in scientific literature rather than "fringe" information or studies.

The section the student added a great deal to, Biotechnology and pharmaceutical applications, begins with a discussion of Maleimide-mediated methods that are used in bio-conjugation as a short, but meaningful, introduction to this important method in organic and biological chemistry. The student appears to add details about how the drug binds to an antibody on a chemical basis, providing important information that was omitted from the reader. Similarly, they added how cysteines are specifically used in biotechnology, or what their purpose is rather than just stating that they are used to form a bond, which does not complete the entire story.

In the following paragraphs, the student addd a wealth of information on retro-Michaels reactions, elimination reactions, and a potential issue with a reaction occurring that is unwanted in the laboratory. I believe that this information could have used some more subheadings or maybe some images including the mentioned reactions to make it clearer for the reader to consume this information if they are perusing it in an introductory sense for potential research. Additionally, more explanation of these reactions in the "Organic chemistry" section could have also facilitated the discussion of the basic chemical reactions that are possible in a lab or in nature. The tone and balance appears to be neutral, stating facts in plain language rather than in a convincing tone for the features of a compound.

Sources appear to be in the past couple of years, demonstrating how essential this compound is for organic chemists and pharmacologists currently. All sources are peer-reviewed. In some other articles, such as mine, more current information on things such as structure are not very recent, since these were elucidated more than two decades ago, but things such as function would, of course, have more recent sources.

I believe that the student did an excellent job to adding more recent research to this article, but could add more to the organization of this article if they have the desire.

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