User:Wagnermr/sandbox

Hey!

My name is Matt, I am a junior at UWM studying biomedical sciences, and one semi-interesting thing about me is that I can speak Spanish. This is one of two Grad-level courses that I am taking this semester. I really look forward to "meeting" and working with you all this semester.

Luteinizing Hormone contribution:
LH production is regulated by Gonadotropin Releasing Hormone (GnRH) from the hypothalamus. (first lil sección de background info)

The Leydig cells produce testosterone under the control of LH. LH binds to LH receptors on the membrane surface of Leydig cells. Binding to this receptor causes an increase in cyclic adenosine monophosphate (cAMP), a secondary messenger, to allow cholesterol to translocate into the mitochondria. In the mitochondria, cholesterol is converted to pregnenolone by CYP11A1. Pregnenolone is then converted to dehydroepiandrosterone (DHEA). DHEA is converted to androstenedione by 3β-hydroxysteroid dehydrogenase (3β-HSD) and then finally is converted to testosterone by 17β-hydroxysteroid dehydrogenase (HSD17B).

(lil sección de "effects in males")

- Note: Androstenedione is rapidly converted to testosterone in the testes

Colesterol translocation -> pregnenolone -> dehydroepiandrosterone -> androstenedione -> testosterone

-> dehydroepiandrosterone -> testosterone ??

Original text in Wiki article: "which regulates the expression of the enzyme 17β-hydroxysteroid dehydrogenase that is used to convert androstenedione, the hormone produced by the testes, to testosterone."