User:WeepingBritney/Nucleosome prof review

Useful information can be obtained here. Used exclusively, they blur the boundaries between science and “copying out of the dictionary”, our favorite form of “research” in elementary school. Supplemented with peer-reviewed review articles, students can profit. Referencing is spotty, contributing to overall lack of clarity of what is well established and what is speculation. Figures (where from?) are generally appropriate; likely lifted from original sources. Most basics are covered for the two areas.

I think that these sites demonstrate that you get what you pay for. They contain many statements that are “true” according to my reading of the literature, as well as quite a few logical but unsupported claims, and some wackiness. I note some of the raised eyebrows below:


 * It is well known that the production of SWI/SNF, a nucleosome remodeling enzyme, is essential for the survival of yeast.[13] However, this limitation can be overcome through various single-residue mutations of either the H3 or the H4 histone. The crystal structures of 11 such mutations have been described[14] and it is possible that their structure may reveal information about how SWI/SNF provides access to genetic sequences initially sequestered through nucleosome wrapping.

''Might be a well-known “fact”, but Swi/Snf mutants in yeast are not lethal; they were first isolated as yeast that demonstrated defects in mating-type switching and sucrose fermentation. It is also a “well-known fact” that if we don’t fight terrorists in Iraq we will have to fight them on our streets here. So beware of “facts”.''