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Templates for individual toxin-antitoxin systems: MazE 19090622 The communication factor EDF and the toxin-antitoxin module mazEF determine the mode of action of antibiotics.

15316771 Escherichia coli mazEF-mediated cell death as a defense mechanism that inhibits the spread of phage P1.

16179604 mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria.

12810711 Characterization of the interactions within the mazEF addiction module of Escherichia coli.

16621839 Induction of Escherichia coli chromosomal mazEF by stressful conditions causes an irreversible loss of viability

11071896 The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome.

12618443 The Escherichia coli mazEF suicide module mediates thymineless death.

17962566 A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli.

15150257 Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions.

Y Yamaguchi, M Inouye - Prokaryotic Toxin-Antitoxins, 2013 - Springer Type II Toxin-Antitoxin Loci: The mazEF Family. The mazEF locus is one of the most extensively characterized toxin-antitoxin (TA) systems. MazF is an endoribonuclease that cleaves RNA at a specific sequence. MazF is conserved in most bacterial and some archaeal species. Since the discovery of MazF in Escherichia coli, a number of MazF homologues and other mRNA interferases with different mRNA cleavage specificities have been elucidated. Here we describe their unique biochemical features, the regulatory mechanisms of the MazF activity and presumed physiological roles of MazF in the cells.

19181798 Regulation of the mazEF toxin-antitoxin module in Staphylococcus aureus and its impact on sigB expression.

22412352 Two Programmed Cell Death Systems in Escherichia coli: An Apoptotic-Like Death Is Inhibited by the mazEF-Mediated Death Pathway. 21183668 The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system.