User:Wiki485921/sandbox

Article evaluation of Uridine Monophosphate:

Often referenced topics composed of multiple words consist of individual links to each word in the term (i.e. "pentose sugar ribose" is linked to three topics, pentose, sugar, and ribose, when it is one concept).

Under biosynthesis it would be helpful to mention (and link) the synthesis pathway that results in the formation of UMP.

This article does not mention the significance of UMP to DNA nucleotide biosynthesis.

Addition to Deoxyuridine Monophosphate article:

Biosynthesis of Deoxyuridine Monophosphate
Deoxyuridine monophosphate (dUMP) is the deoxygenated form of uridine monophosphate (UMP), and is the precursor to deoxythymine monophosphate (dTMP), a component of DNA nucleotide biosynthesis. By replacing the hydroxyl group at the 2' carbon of ribose with a hydrogen, UMP becomes deoxygenated to dUMP.

The synthesis of deoxyuridine monophosphate (dUMP) is a multi-step process that begins with uridine monophosphate (UMP), the product of pyrimidine biosynthesis. The enzyme nucleoside monophosphate kinase converts UMP and ATP to uridine diphosphate (UDP) and ADP.

In the presence of excess ATP, the enzyme ribonucleotide reductase initiates a chain reaction with UDP, which catalyzes the formation of deoxyuridine diphosphate (dUDP), which is then converted to deoxyuridine triphosphate (dUTP), then deoxyuridine monophosphate (dUMP) via the addition or removal of phosphate groups.