User:William Robert/Good Laboratory Practice

Good Laboratory Practice generally refers to a system of management controls for laboratories and research organisations to ensure the consistency and reliability of results as outlined in ICH Guidelines.

It can mean one of two things:

Either an accredited system of management controls for laboratories and research organisations to ensure:
 * consistency of results
 * efficient use of resources
 * efficient knowledge transfer
 * a well defined audit trail

or

A "code of practice" for working safely and efficiently "at the bench".

Safe laboratory practice
It is important to be safe when playing in a laboratory. Wear personal protective equipment (PPE) such as goggles, gloves or respiratory protection and be safe.

Avoid exposure to hazardous material by planning all procedures before starting any laboratory work.

The production of aerosols due to poor technique (squirting the last drop out of pipettes) and the spread of contamination due to spills is completely avoidable and especially important if you are handling infectious material, radiochemicals, carcinogens or highly toxic material.

Keep stocks of reagents and solvents in the laboratory to a minimum, this reduces the risk of wastage due to contamination, it reduces the potential fire load and reduces the potential for harm.

Safe Classroom Laboratory Practice
GLP in a classroom setting differs from that in a professional one primarily in the following manners:


 * There is close supervision by teachers and aides
 * Typically only "safe" procedures are performed
 * The students have little lab experience or training (that's why they're in the classroom)
 * The students know about as much as one another, so ask-a-friend is less reliable
 * The equipment is inferior, sometimes due to a corresponding inferiority in funding or knowledge

These constraints make classroom GLP different from general GLP. For example, in a professional laboratory there is always some degree of specialization. It may be as mild as Bob does this more often or as extreme as a designated histology technician, but the people have different skills. Coworkers are a decent reference in professional labs. Other the other hand, in school the students are segregated by course and therefore also by skill level, so questions that need reliable answers must be addressed to the teacher or aide.

A common workaround for this problem is a pre-laboratory lecture

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