User:Willpidduck/sandbox

To date, Forty-one ion-channel genes and over 1,600 ion-channel mutations have been implicated in the development of epileptic seizure. These ion channel mutations tend to confer a depolarized resting state to neurons resulting in pathological hyper-excitability. Equally important in epileptic neuronal hyper-excitability, is the reduction in the activity of inhibitory GABAergic neurons, an effect known as disinhibition. Disinhibition may result from inhibitory neuron loss, dysregulation of axonal sprouting from the inhibitory neurons in regions of neuronal damage, or abnormal GABAergic signaling within the inhibitory neuron.

Comments
Thanks for the suggestions. I have a few short notes: JenOttawa (talk) 03:08, 6 November 2018 (UTC)
 * Can you try to use more lay terms? Etiology, for example, can be replaced. You can also modify other sections to make them more understandable to someone who does not have a medical/science background. It is hard to do for this type of content!
 * You can probably add a few wikilinks to some of the terms used (even ion channel!)
 * Remove the "To date" part. See WP:Manual_of_Style/Words_to_watch
 * Good work inserting your citations!