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Murine Astrovirus is an astrovirus within the mamastrovirus genus. It infects both wild mice and laboratory mice. In laboratory mice, both immunocompetent and immunodeficient strains could be infected with murine astrovirus. Some immunocompromised mice were shown to be infected with murine astrovirus chronically. The pathogenicity of the murine astrovirus was not known.

Prevalence
A recent study detected a murine astrovirus in laboratory mice held at more than half of the US and Japanese institutes investigated. Murine astrovirus was detected in nine mice strains, including NSG, NOD-SCID, NSG-3GS, C57BL6-Timp-3-/-, uPA-NOG, B6J, ICR, Bash2, and BALB/C, with various degree of prevalence.