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The Mobetron is the only portable, self-shielded electron linear accelerator designed to deliver intraoperative radiation therapy (IORT) to cancer patients during surgery. The system was invented and commercialized by IntraOp Medical Corporation (IntraOp) in 1997 under the leadership of Donald Goer and cofounders Russ Schonberg, Mary Louise Meurk, Jerry Vaeth, and Gene Haynes. The Mobetron has made it possible to use linear accelerator (LINAC)-based radiation for cancer treatment in a standard operating room without the need for shielding.

Practiced since the late 1960s, electron IORT had historically only been possible using traditional linear accelerators in shielded bunkers. This was a major hindrance to the adoption of IORT as it added significant cost to treatment and logistical complications to surgery. The growth of portable linear accelerators, like the Mobetron, has changed patient care by bringing self-shielded radiation technology into the operating room. By delivering intraoperative radiation therapy (IORT) to cancer patients during surgery, the Mobetron improves the quality of life for patients.

The Mobetron made electron IORT portable by leveraging X band LINAC technology combined with redundant shielding and an integrated beam stopper. The Mobetron’s two X-band 9.3 GHz collinear accelerators generate X-band waves, which are part of the microwave radio wave region in the electromagnetic spectrum. In the Mobetron and other LINACs, particles ride on the electromagnetic waves, and their frequency is measured in the number of waves per second; the higher the frequency the higher the amount of energy a particle gains in a specified distance.

Because it generates higher frequencies than other wave energies, X-band technology can reduce LINAC size by 66%, creating lighter, more compact linear accelerators that need less shielding. The Mobetron is one of only two medical linear accelerators in the world to employ X-band technology. Combining this technology with self-shielding, the Mobetron is a highly safe portable radiation device with very low stray radiation contained in a small foot print. The average radiation exposure to operating room personnel during a Mobetron treatment is 1/10th the exposure a passenger receives on a transoceanic airline flight. Consequently, the Mobetron’s self-shielding and ability to operate in an electron mode of up to12 MeV make it safe to use in an unshielded operating room.

The Mobetron’s portability does not affect its short- or long-term stability in regards to dose output and energy: Research indicates that the Mobetron’s stability is equivalent to that of nonportable linear accelerators.

In addition, the Mobetron’s soft docking laser alignment system ensures patient safety by decoupling the machine from the electron applicator if some uncontrolled motion occurs and the patient is not positioned correctly. Treatment stops immediately until proper alignment is achieved. The Mobetron has treated over 15,000 patients in fourteen different countries around the world.

== Technical Features ==
 * Energies: 6,9,12 MeV
 * Depth: 1-4 cm D80
 * Stray Radiation: less than 6µSv @ 3 meters
 * Motion Control:
 * Rotation: +/- 45 degrees
 * Tilt +10 degrees / - 30 degrees
 * Lateral/Longitudinal: +/- 5cm
 * Vertical: 30cm
 * Soft docking laser alignment system
 * QA System: AAPM TG72 Compliant

Clinical Uses
The Mobetron and electron IORT have been used to treat over 20 different types of cancer. The most common cancers treated by the Mobetron are breast cancer, pancreatic cancer, colorectal cancer, sarcomas, head and neck cancers, and GYN cancers. Research is currently underway to expand the use of the Mobetron to include brain cancer, bladder cancer, esophageal cancer, gastric cancer, lung cancer, prostate cancer, spinal metastases, and pediatric cancer, including neuroblastoma.

United States

 * Advocate Christ Medical Center, Chicago, Illinois, USA
 * Avera Regional Hospital, Sioux Falls, South Dakota, USA
 * Case Western University (UHHS), Cleveland, Ohio, USA
 * Ohio State University James Cancer Hospital, Columbus, Ohio, USA
 * Massachusetts General Hospital, Boston, Massachusetts, USA
 * Mayo Clinic-Jacksonville, Jacksonville, Florida USA
 * Mayo Clinic-Scottsdale, Scottsdale, Arizona, USA
 * Oregon Health and Science University, Portland, Oregon, USA
 * St. Joseph's Hospital, Orange, California, USA
 * St. Luke's Hospital, Cedar Rapids, Iowa, USA
 * St. Vincent's Hospital, Indianapolis, Indiana, USA
 * Scripps Health, La Jolla, California, USA
 * Stanford Hospital and Clinics, Palo Alto, California, USA
 * University of California at San Francisco #2, San Francisco, California, USA
 * University of California at San Francisco #3, San Francisco, California, USA
 * University of North Carolina, Chapel Hill, North Carolina, USA
 * University of Washington, Seattle, Washington, USA

South America
Instituto Nacional de Cancerologia, Bogata, Bogata, Columbia

Austria

 * Krankenhaus Der Barmherzigen Schwestern, Linz, Oberösterreich, Austria

Belgium
Centre Universitaire Hospitalier De Tivoli, La Louvière, Hainaut, Belgium Institut Jules Bordet, Brussels, Brabant, Belgium Sint Augustinus, Antwerp, Flanders, Belgium

England
University Hospital, South Hampton, South Hampton, England

Germany

 * Helios Klinikum Berlin-Buch, Berlin, Berlin, Germany
 * Marien Hospital, Dusseldorf, North Rhine-Westphalia, Germany
 * St. Elisabeth Krankenhaus, Cologne, North Rhine-Westphalia, Germany
 * University of Heidelberg, Heidelberg, Gauteng, Germany
 * University Klinikum Freiburg, Freiburg, Baden-Württemberg, Germany
 * University Klinikum Marburg, Marburg, Hesse, Germany

Italy

 * Azienda Ospedaliera Santa Croce E Carle, Cuneo, Cuneo, Italy
 * CRO Aviano, Aviano, Pordenone, Italy
 * Ospedale Borgo Trento-Universitaria Od Verona, Verona, Verona, Italy
 * Ospedali Riuniti, Trieste, Trieste, Italy
 * Ospedale Maggiore della Carita-Universitaria of Novara, Novara, Italy

Netherlands

 * Mch Westeinde, The Hague, South Holland, Netherlands
 * Caterina Ziekenhuis, Eindhoven, Netherlands

Poland

 * Centrum Onkologii, Bydgoszcz, Kuyavian-Pomeranian, Poland
 * Wielkopolskie Centrum Onkologii, Poznan, Poznan, Poland

Turkey

 * Ankara Oncology State Hospital, Ankara, Ankara, Turkey
 * Istanbul Oncology State Hospital, Istanbul, Istanbul, Turkey

China

 * Beijing General Hospital (PLA301), Beijing, Hebei, China
 * Beijing Tumor Hospital (CAMS), Beijing, Hebei, China
 * China Medical University, Shenyang, Liaoning, China
 * Peking Union Hospital, Beijing, Hebei, China
 * PLA 307 Hospital, Beijing, Hebei, China
 * Shanghai Tumor Hospital, Shanghai, Jiangsu, China
 * Shanghai Ruijin Hospital, Shanghai, Jiangsu, China
 * Xuanwu Hospital, Beijing, Hebei, China

Japan

 * Gunma Prefectural Hospital, Gunma, Kantō, Japan
 * Nagoya University Hospital, Nagoya, Chūbu, Japan

Saudia Arabia

 * King Faisal Specialist Hospital & Research Center, Riyadh, Mintaqah, Saudi Arabia
 * King Khalid University Hospital, Riyadh, Mintaqah, Saudi Arabia

Thailand

 * Siriraj Hospital-Mahidol University, Bangkok, Bangkok, Thailand