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Using a prospective cohort model, the investigators sought to examine the entire population of the county aged over 40 years and half the population aged between 15 and 39 years. They ultimately achieved a 92% response rate for a total study population of 3,102 residents. From 1960-1962, each participant was given an initial examination in which serum cholesterol, blood pressure, weight, height and the participant’s responses to a number of health behavior and medical history questions. A follow-up consisting of a similar battery of tests was completed from 1967-1969. For 90.9% of the study population, a physical similar to the preliminary one was completed. For another 7.9%, health status was ascertained by a phone survey of either subject or a family member. The total rate of follow-up was 98.8%. Factors assessed at the time of follow-up were systolic and diastolic blood pressure, serum cholesterol level, cigarette smoking, body weight, hematocrit value, ECG abnormalities and diet. Socioeconomic status was also assessed for whites, but not for blacks, as little variability was found in this factor among black subjects.