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a high-intensity (3-5RM), long rest interval (3 min) resistance training program was more effective than a high-volume protocol with short rest intervals (10–12 RM, 1 min) for stimulating changes in isometric force production and RFD in resistance-trained men.

During a HI-RT session, MUs recruitment pattern follows the size principle, in which the low threshold MUs are recruited first, followed by high threshold MUs

Studies suggest that fatigue caused by muscular failure may be related to greater muscle activation, which would explain the greater increases in muscle strength when performing repetitions to failure, at least for strength trained individuals.

evidence regarding untrained subjects, it seems plausible to suggest that HI-RT to failure is not necessary for maximal increases in strength and hypertrophy. On the other hand, repetitions to failure seem essential for increases in muscle strength and mass of similar magnitude to HI-RT when performing LI-RT. When it comes to trained individuals, evidence show greater increases in muscle strength after HI-RT performed to muscle failure compared to no failure.