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Xavier University College of Pharmacy (APPE Rotation 4 Fall 2017) - ARTICLE EVALUATION

Chelsea James

Meglitinides Article Mostly everything was relevant to the topic besides the last portion of the article. The study with the rats threw me off and I did not feel it was appropriate because it may potentially scare patients who are currently on or who may be prescribed these medications. The first source works but it is all in a different language therefore I cannot determine if the claims in the article are supported. The other two sources from the FDA worked as well and the sources did support claims in the article. The only fact that I would not consider cited by a reliable reference would be any references to the first citation. Two sources come from the FDA website and I would consider that to be a neutral source, however the first source comes from a different site and I would not say this is a neutral source it is biased to whatever language the whole website is in.
 * Is everything in the article relevant to the topic? Is there anything that distracted you or you felt was inappropriate?
 * Check a few citations. Do the links work? Does the source support the claims in the article?
 * Is each fact referenced with an appropriate, reliable reference? Where does the information come from? Are these neutral sources? If biased, is that bias noted?

Check out the Talk Page of the article. What kinds of conversations, if any are going on behind the scenes about how to represent this topic?

There are currently no conversations going on about this article.

Is any information out of date?

The only citation that is out of date is the first one and I cannot read it, the date is from 2006. However the other two sources are fine.

How is the article rated?

It is rated a stub class on the project quality scale. It is rated high importance on the project importance scale.

Is it part of any WikiProjects?

Yes it is a part of WikiProjects Pharmacology.

What changes do you suggest?

I believe the article is short and sweet and to the point. Glufast needs to be sectioned off into what areas of the world it is available where it is not available in the USA. There needs to be dosages added and any possible drug drug interactions as well. Since patients may look to Wikipedia for the cost as well, putting manufacturer coupon websites may be a helpful tool.

Bibliography- Drug Drug Interactions

What needs to be added? Drug drug interactions with the Meglitinide class, to start the interaction with Prandin and Gemfibrozil with or without the concomitant use of itraconazole this article is about this interaction: Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism (Pub Med). Rifampicin and how it effects concentration of Starlix, this article relates to this interaction: Effect of rifampicin on the pharmacokinetics and pharmacodynamics of nateglinide in healthy subjects (PubMed), Prandin and the potential interaction with trimethoprim, the supporting article: The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects.

Taylor McBride- Meglitinides

Is everything in the article relevant to the topic? Is there anything that distracted you or you felt was inappropriate? I think that the article was pretty simple and straightforward in explaining Meglitinides. I think that the mechanism of action part could have been simplified more and explained more about the pancreatic beta cells and how they work to lower blood sugar rather than going into the depolarization of Ca2+ voltage gated channels. Do the links Work? Does the source support the claims in the article? The links work but i’m not sure if the first link is a reliable source. The mechanism of action came from the first link but it wasn’t referenced. The second and third links were used in the side effects section. I think that the side effects section could have been a little more detailed since that is what most people want to look up any way. Is each fact referenced with an appropriate reliable reference? The paragraph with the mechanism of action did not have any references. The side effects paragraph didn’t have any references either. The facts about Repaglinide causing an increased incidence of adenomas of the thyroid and liver in rats but not seen with nateglinide was properly referenced.

Nandi Wilkerson- Evaluating Meglitinides Article Is everything in the article relevant to the topic? Is there anything that distracted you or you felt was inappropriate? No, everything in the article is not relevant to the topic. The study on the rats was irrelevant and distracting. The article that stated it even recognized that the correlation between the male rats and humans are unknown. Check a few citations. Do the links work? Does the source support the claims in the article? The citation links do work. The first source did support the claims in the article, however it was for france and was in French. The other Prandin sources did support the claim made, however startlix article did not. Is each fact referenced with an appropriate, reliable reference?

I don’t think the first reference is appropriate reference due to where it comes from, the other two are.

What needs to be added? Better data to as supporting evidence behind claims about the drugs efficacy.

Repaglinide (248 participants in three trials) had a similar degree of effect in reducing glycosylated haemoglobin as metformin. Weight gain was generally greater in those treated with meglitinides compared with metformin (up to three kg in three months). Diarrhoea occurred less frequently and hypoglycaemia occurred more frequently but rarely severely enough as to require assistance. Combined metformin and repaglinide therapy resulted in superior glycemic control compared with repaglinide or metformin monotherapy in patients with type 2 diabetes whose glycemia had not been well controlled on metformin alone. Repaglinide monotherapy was as effective as metformin monotherapy.

Start compiling a list of relevant, reliable books, journal articles, or other sources as well. You should have at least 5 sources here to support the information that you think should be added to increase the validity of this article.

Black C, Donnelly P, McIntyre L, Royle P, Shepherd JJ, Thomas S. Meglitinide analogues for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD004654. DOI: 10.1002/14651858.CD004654.pub2. Link to Cochrane Library. [PubMed]

http://hopkinsdiabetesinfo.org/medications-for-type-2-diabetes-sulfonylureas-and-meglitinides/

http://www.sciencedirect.com/science/article/pii/B9780128029497000079

http://care.diabetesjournals.org/content/22/1/119