User:Yanping Nora Soong/biochemnotes

=GC Adv Biochem II BICM 71020=

Week 1

 * Metabolic control analysis

Papers

 * Why did nature choose phosphates?
 * Metabolic control analysis papers

Week 2

 * Glycolysis v. Gluconeogenesis
 * Cori cycle
 * Fructose 2,6-bisphosphate and AMP as regulators of Phosphofructokinase
 * PFK-1 / PFK-2


 * Neuronal and hepatocyte isozymes of PFK-1


 * Glucose transporters
 * GLUT1 (facilitated diffusion)
 * GLUT2 (liver/pancreas)
 * SGLT1 (symporter)

Week 3

 * GPCRs
 * beta-1 adrenergic receptor
 * activates Gs alpha subunit

Supplement

 * Mechanisms of insulin resistance

Week 4

 * Warburg effect
 * Regulation of pyruvate dehydrogenase
 * Kinase / phosphatases
 * Product inhibition
 * Allosteric regulators

Week 5

 * Ketogenesis
 * Cytosolic oxaloacetate is converted to malate. Two fates
 * Malate can be converted to pyruvate
 * Malate can enter the mitochondria and be converted into oxaloacetate


 * Four major repeating steps of fatty acid synthesis
 * Condensation (ELOVL)
 * Reductase
 * Dehydratase
 * Reductase

Week 6

 * Phenylketonuria
 * Branched-chain amino acid catabolism (deficiency v. excess)
 * Pyridoxal phosphate

Week 8

 * Mobility of proteins in lipid bilayer
 * Fluorescence recovery after photobleaching (FRAP)
 * Fluorescence loss in photobleaching

Final

 * Pentose phosphate pathway
 * Purine biosynthesis
 * Transporters
 * GLUT1
 * GLUT4 (insulin-dependent)