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Chi-Ming Che (支志明), born in 1957 in Hong Kong, is currently a Dr. Hui Wai-Haan’s Chair of Chemistry at The University of Hong Kong (HKU), Hong Kong, China. Also, since 1995, he has been a member of Chinese Academy of Science in China; where he was the first elected member from Hong Kong. [1] He is known for extensive work in inorganic chemistry, photochemistry and medicinal chemistry. [2]

Career

Chi-Ming Che received his B.S. degree at HKU in 1978. He then received his Ph. D degree in inorganic chemistry at HKU working under Professor Chung-Kwong Poon in 1980. After earning his Ph. D., he spent 3 years at California Institute of Technology conducting research in organometallic and bioinorganic chemistry in [null the laboratory of Harry B. Gray][pw1] . [1] [3]

Following his research stay in the United States, Che moved back to China and started his independent career as a faculty at HKU. During the past 20 years, he has also held visiting lecturer positions at National Taiwan University, Jilin University, Sun Yat-Sen University. Moreover, he has been a professor at Najing University, Nankai University, and Tsinig Hua University; and an honorary professor at Huazhong University of Science and Technology, Northeast Normal University, Nanjing University, and other universities.[1]

Currently, he is the Chair Professor of the Department of Chemistry at The University of Hong Kong. [1]

Research

Che’s research interests cover various areas in chemistry such as inorganic chemistry, materials science, photochemistry and biomedical sciences. [4] [5] He has been engaged in inorganic chemistry research, organometallic synthesis where he and his group have studied high-valent and multimetallic complexes [10]. These molecules have been investigated for their luminescent and catalytic properties. [null Notable systems that Che has developed include: catalysts for asymmetric olefin epoxidation, biomimetic oxidation catalyst featuring recognition elements, and molecular devices based on luminescent materials]

Che has pioneered the developed of Ru-OXO system which has opened up numerous opportunities for efficient catalytic oxidation processes. [11] [12] [pw2]

Figure 1: Epoxidation and Cyclopropanation of Alkene Based on Using Ru (III) Catalyst.

Ruthenium (III) porphyrin functionalized with PEG group is used as a catalyst to drive selective pathway of alkene to epoxide or cyclopropane.

Furthermore, Che and co-workers developed new methods for epoxidation, cyclopropanation, and aziridination of alkenes. [7] [13]. His work on bioinorganic chemistry, has produced new understanding for several important processes including modern nitrogen fixation. [6]

Another notable work from Che’s group has been the development of gold-based organometallic compounds with antitumor activity. [8] [9] [14] Specifically, they found that [null PEGylated gold(III) conjugates] can exhibit multifunctional properties and undergo selective delivery to tumor tissues. Importantly, some of these compounds do not exhibit harmful cytotoxicity to normal cells, as many Pt-based anti-cancer agents do [8] [9].

Notable Awards

2006 First Class Prize of the State Natural Science Award of China

2006 TWAS Prize in chemistry from the Academy of Sciences for the Developing World

2013 Royal Society of Chemistry (RSC) Centenary Prize

References
 * 1) Prof. C.M. Che - http://www.chemistry.hku.hk/staff/cmche/cmche.htm .     Hku.hk. Retrieved 10 May 2017.
 * 2) Chi-Ming Che. http://www.nasonline.org/member-directory/members/20030487.html .     National Academy of Sciences. Retrieved 9 May 2017.
 * 3) Chi-Ming CHE. http://www.ashk.org.hk/en/ourMembers/details/34 . The Academy of Sciences of Hong Kong. Retrieved 11 May 2017.
 * 4) Professor CHE Chi Ming[null .] https://croucher.org.hk/professor-che-chi-ming . Croucher Foundation.     Retrieved 9 May 2017.
 * 5) FACS Newsletter 2003 (2) Prof.     Chi-Ming Che. http://www.facs-as.org/a77.html . Federation of Asian Chemical Societies, FACS.     Retrieved 10 May 2017.
 * 6) Chi-Ming     Che, Hon-Wah Lam, Wai-Fong Tong, Ting-Fong Lai and Tai-Chu Lau.  “Model reactions for nitrogen fixation.     Photo-induced formation and X-ray crystal structure of     [Os2(NH3)8(MeCN)2(N2)]5+ from [OsVI(NH3)4N]3+”. Journal of the Chemical     Society, Chemical Communications. Retrieved 4 Jun 2017.
 * 7) Jun-Long     Zhang and Chi-Ming Che. “Soluble Polymer-Supported Ruthenium Porphyrin     Catalysts for Epoxidation, Cyclopropanation, and Aziridination of     Alkenes.” Org.Lett, 2002, 4 (11), pp 1911-1914. Web. 12 May 2017.
 * 8)  Ching Tung Lum, Xiong    Liu, Raymond Wai-Yin Sun, Xiang-Ping Li, Ying Peng, Ming-Liang He, Hsiang     Fu Kung, Chi-Ming Che, Marie C M Lin. “ Gold(III) Porphyrin 1a Inhibited     Nasopharyngeal Carcinoma Metastasis in Vivo and Inhibited Cell Migration     and Invasion in Vitro”. Cancer Lett 294 (2), 159-166. 2010 Feb 16.     Web. 21 May 2017.
 * 9) Clive Yik-Sham Chung, Sin-Ki     Fung, Ka-Chung Tong, Pui-Ki Wan, Chun-Nam Lok, Yanyu Huang, Tianfeng Chenb     and Chi-Ming Che. “ A multi-functional PEGylated gold(III) compound:potent     anti-cancer properties and self-assembly into nanostructures for drug     co-delivery”. Chemicalscience. 2016 Nov 8. Web. 21 May 2017
 * 10) Chi Ming. Che and Wing Kin.     Cheng.”Novel UV-vis spectral feature and electrochemical behavior of     high-valent osmium(VI) dioxo complex of     1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane (TMC). Reversible     three-electron redox couple and vibronic structured UV-vis absorption     bands involving trans-[Os(VI)(TMC)O2]2+” Journal of the American Chemical     Society 1986 108 (15), 4644-4645. DOI: 10.1021/ja00275a062
 * 11) Chi-Ming  Che, Clare Ho, and Tai-Chu Lau. “Turning the reactivities of ruthenium-oxo     complexes with robust ligands. A ruthenium(IV)-oxo complex of 6,6’-dichloro-2,2’-bipyridine     as an active oxidant for stoichiometric and catalytic organic oxidation.” Journal of the Chemical Society,     DaltonTransactions 1991, 1901-1907. DOI: 10.1039/DT9910001901.
 * 12) Chi Ming Che and Vivian Wing Wah Yam. “ Model complexes for the cis-ruthenium(VI)-dioxo system. Novel     chemistry of [RuIII(N4O)(OH2)][ClO4]2 (N4OH =     bis[2-(2-pyridyl)ethyl][2-hydroxy-2-(2-pyridyl)ethyl]amine).” Journal of     the American Chemical Society 1987 109 (4), 1262-1263. DOI:     10.1021/ja00238a055
 * 13) Chi-Ming Che, et al. “Highly     Diastereoselective Epoxidation of Allyl-substituted cycloalkenes Catalyzed     by Metalloporphyrins” Org. Lett.,     2004, 6 (10), pp 1597-26++. DOI” 10.1021/o10496475
 * 14) Chi-Ming Che, and Taotao Zuo. “Novel Gold     (III) Complexes Containing N-Heterocyclic Carbene Ligands, Synthesis, and     Their Applications in Cancer Treatment and Thiol Detection” The HKU     Scholar Hub. World Intellectual Property Organization (WIPO), PatentScope,     2014.