User:Yayinruan/NAD+ glycohydrolase/Petvyli Peer Review

General info
Yayinruan
 * Whose work are you reviewing?


 * Link to draft you're reviewing:User:Yayinruan/NAD+ glycohydrolase
 * Link to the current version of the article (if it exists):NAD+ glycohydrolase

Evaluate the drafted changes
(Compose a detailed peer review here, considering each of the key aspects listed above if it is relevant. Consider the guiding questions, and check out the examples of what feedback looks like.)

What the article does well:

She created a new section called Immunoregulation. Her lead sentence is clear and straight to the point. "NADase is important to regulating adaptive immunity as T cells contain enzymes such as CD38 and SARM1 that consumes NAD+." She then talks more about these enzymes in two new sections increasing clarity. A change I would suggest is some of the phrasing in CD38 section is a bit confusing. For example: "Cells that are programmed for cell death or apoptosis releases NAD+, and type II CD38 help recycle the extracellular NAD+ released from apoptosis, where both products of NADase, ADP-ribose and nicotinamide, can be used to resynthesize NAD+ via the NAD+ synthesis pathway." I think this can be broken down into two sentences and there is a minor spelling error of NDAse.

Reformatted:

Cells that are programmed for cell death (apoptosis) releases NAD+, and type II CD38 help recycle this extracellular NAD+. ADP-ribose and nicotinamide, products of NADase, can be used to resynthesize NAD+ via the NAD+ synthesis pathway."

This is out of curiosity but I would like some explanation behind the meaning of CD38 and SARM1. They are enzymes but where did the name come from and why those numbers?

She has a good lead sentence that I can apply to my own article.

Overall, it has a clear structure. She added a specific section on how this enzyme can regulate immunity but there was already information on the general function so it's a balanced coverage. She speaks in a neutral tone and she cites from reliable sources. I think she contributed well to this topic.