User:Yazoo96/sandbox

The endocrine disrupting nature of BPS has encouraged investigations into its affinity to estrogenic receptors, showing BPS to be a weak agonist; similar in potency to BPA, which it has come to substitute. Select studies show BPS to be capable of mimicking oestradiol, and sometimes being more effective. The estrogenic activity of BPS has been demonstrated through in vivo rodent studies, inducing growth of the womb, with a range of dosages. These are pathways necessary for cell function, cell cycle regulation, and neuroendocrine induced behaviours which are important for reproduction. BPS has shown to both disrupt signalling and damage DNA. Androgenic and antiandrogenic activity have also been confirmed by BPS disrupting function of the androgen receptors. Studies on zebrafish have shown decreased egg quality, reduced sperm count, an increased frequency of embryo abnormalities, as well as changes in the mass of gonads; suggesting that BPS is a reproductive toxin for both sexes.