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A 2012 meta-analysis showed that prostaglandin inhibitors and calcium channel blockers had the most effective tocolytic therapy at delaying delivery and improving neonatal mortality and maternal outcomes when comparing with the top three medication classes, beta mimetics, magnesium sulfate, and calcium channel blockers.

Indication
Tocolytics are used in preterm labor, which refers to when a baby is born too early before 37 weeks of pregnancy. The goal is to reduce neonatal morbidity and mortality through delaying delivery and increasing gestational age by gaining more time for corticosteroids therapy as preterm birth represents one of the leading cause of neonatal morbidity and mortality.