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Overview of PCNX4
Pecanx-4 (PCNX4) is a protein encoding gene located on Homo sapiens' chromosome 14 open reading frame 135. PCNX4 is a novel gene expressed in 27 different tissue types, but most abundantly in brain, endometrium, prostate, and adrenal tissue. Its pecanex-like protein 4 has 15 transmembrane regions and two glycosylation sites; its molecular weight is approximately 133 kDa with an amino acid makeup of 1,172. Other names for this gene are: PCNXL4, C14orf135, Chromosome 14 open reading frame 135, Hepatitis C Virus F Protein-Binding Protein 2, and HCV F Protein-Binding Protein 2. PCNX4 has two isoforms with isoform 1 being the longest while isoform 2 has missing exons or shorter N-terms.

Gene
The protein sequence of PCNX4 includes 15 transmembrane regions, 2 glycosylation sites, and 12 exon

PCNX4 is a protein encoding gene located on chromosome 14 in Homo sapiens at location q23.1 (see Figure X). It is expressed predominately in the endometrium, prostate, and adrenal, but is known to be expressed in 27 total tissue types. An important paralog to PCNX4 is PCNX3. PCNX1 and PCNX 2 exists, but they are not as closely related to PCNX4.

Figure Y demonstrates the neighboring genes to PCNX4: LRRC9 and DHRS7 (Original image retrieved from NCBI Gene Database). DHRS7 is expressed most in the prostate—a dehydrogenase/reductase; while LRRC9 is expressed most in the testis—a leucine rich repeat.

Figure X. Annotated Homo sapiens chromosome 14. Shaded areas demonstrate gene locations on the chromosome. PCNX4 is indicated by the red line at shaded region q23.1. The gene is also located on the plus-strand (Original image retrieved from GeneCard).

Orthologs
PCNX4 is found to have around 600 vertebrate orthologs and between 1-3 paralogs. Some additional orthologs include invertebrates such as

Gene expression
Overall, these **figures** provide an interesting find of PCNX4 in various locations, but there are some clear levels of expression such as in reproductive tissues, brain, and GI organs.

Protein localization
TBA