User:Zeinabalimadadi

theory of imbalance in autonomic nervous system this theory indicates that there are four types of imbalance between sympathetic and parasympatic activity accordingly

A hyperactivity of sympathetic + hyperactivity of parasympatic B hyperactivity of sympathetic + hypoactivity of parasympatic C hypoactivity of sympathetic + hyperactivity of parasympathic D hypoactivity of sympathetic + hypoactivity of parasympathic

the first idea of this hypothesis came from the association between dermatitis and neurodegenerative disease of Parkinson later the fact vagal nerve stimulation is an accepted and standard treatment for major depressive disorder bring another evidence that parasymatic hypoactivity could have an important roll in development of this hypothesis

recently major depressive disorder has considered as an inflammatory state with increased IL-6 and IL-1 but vagal nerve stimulation modulates immune system