User:Zenografia

Biography Juan R. Sanchez-Ramos, PhD, MD is a distinguished physician-scientist born in Venezuela, July 16, 1945. He currently resides in Tampa, Florida where he is the “Helen Ellis Endowed Chair in Parkinson’s Disease Research” in the Department of Neurology, University of South Florida College of Medicine. His faculty profile can be seen below: https://health.usf.edu/medicine/neurology/profiles/9497/Sanchez-Ramos Education University of Chicago, BS in Biochemistry (1963-1967) University of Chicago, PhD in Pharmacology and Physiology (1971-1976) University of Illinois, Chicago, MD (1978-1981) University of Chicago, Internship and Residency in Neurology(1981-1985) Research Topics Disorders of the Basal Ganglia (Movement Disorders). Neurotoxicty of environmental agents for dopamine neurons. Huntington's disease (HD) natural history and search for the HD gene <<1>> Neurogenesis from adult tissue bone marrow, and promotion of neurogenesis with granulocyte-colony stimulating factor (G-CSF)<<2,3>> Development of a non-invasive approach for chronic, intermittent delivery of gene-silencing molecules packaged in nanoparticles that can be instilled into the nasal cavity <<4,5>>. Published works Go to OrcID https://orcid.org/0000-0002-3391-7857 for list of published work by Dr. Sanchez-Ramos. Honours, decorations, awards and distinctions NIH pre-doctoral fellowship, Dept of Pharmacological and Physiological Sciences, University of Chicago, (1971-1976) James Scholar Program of Independent Studies, University of Illinois College of Medicine (1978 83) Bertram A. Richardson Foreign Scholarship (1981) Clinical Investigator Development Award (NIH) 1989 1991 "Prix de la qualite de la Realisation technique" awarded during Concours International des Technolgie de la Creation held in Paris, 19 November, 1991 for hologram entitled "Crystal Dreams" Helen E. Ellis Endowed Chair in Parkinson’s Disease Research (1996) University of South Florida Outstanding Research Award for nationally recognized research on transdifferentiation of bone marrow stromal cells to neural cells (2003) Award for animation entitled “Dancing DNA” sponsored by the University of Chicago Materials Research Center in their annual Sights and Sounds of Science Project (2004) Patents Mash D, Sanchez-Ramos J, and Hearn L. “A Method of Treating Chemical Dependency in Mammals and A Composition Thereof” United States Patent Office (Awarded Feb 19, 2002) # 6,348,456 Sanchez-Ramos, J, S. Song, P. Sanberg, W. Janssen, T. Freeman. “Bone Marrow Cells as a Source of Neurons for Brain and Spinal Cord Repair” United States Patent Office (Awarded March 3, 2003 # 6,528,245 B2 Sanberg, P, Sanchez-Ramos J, Willing A, Richard, DD. “Human Cord Blood As A Source Of Neural Tissue For Repair Of The Brain And Spinal Cord” United States Patent Office (Awarded Jan 9, 2007 Patent # 7,160,724 B2) Sancez-Ramos, J. Richard Heller and Mark Jaroszeski.  “Nervous Tissue Electrode Device” United States Patent Office (Awarded July 19, 2007 Patent  # 0167903 A1 Song S, Sanchez-Ramos J.  “Promotion of Brain Self-Repair by Stereotaxic Micro Stimulation” US Pat 8,452,408 Sanchez-Ramos, J Sava, V, Song S, Mohapatra, S.  Divalent-Metal Coated Nanoparticles For Delivery Of Compositions Into The Central Nervous System By Nasal Insufflation U.S. Patent No. 9,938,526 B2 Bibliography from this Article 1. Penney JB, Jr., Young AB, Shoulson I, Starosta-Rubenstein S, Snodgrass SR, Sanchez-Ramos J, et al. Huntington's disease in Venezuela: 7 years of follow-up on symptomatic and asymptomatic individuals. Mov Disord. 1990;5(2):93-9.	2. Sanchez-Ramos JR. Neural cells derived from adult bone marrow and umbilical cord blood. Journal of Neuroscience Research. 2002;69(6):880-93. 3. Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, et al. Granulocyte Colony Stimulating Factor Decreases Brain Amyloid Burden And Reverses Cognitive Impairment In Alzheimer's Mice. Neuroscience. 2009;163(1):55-72. 4. Sanchez-Ramos J, Song S, Kong X, Foroutan P, Martinez G, Dominguez-Viqueria W, et al. Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain. J Drug Deliv Sci Technol. 2018;43:453-60 5. Sava V, Fihurka O, Khvorova A, Sanchez-Ramos J. Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration. Nanomedicine: Nanotech, Bio and Med. Volume 24, February 2020 https://doi.org/10.1016/j.nano.2019.102119