User:Zhongyiw/sandbox

In vivo applications
A peer-reviewed paper by Schaefer et al raised concerns on unexpected off-target changes in CRISPR in vivo editing. The paper was criticized and retracted due to its lack of key controls. But it also pointed out the potential disadvantage of CRISPR need further reassessment in in vivo applications. Recent studies are taking whole-genome methods into consideration for comprehensive understanding of CRISPR off-target effects.

Identification
...Programs used for CRISPR ... in long sequence..

in genome: chopchop (Many tools since 2007)