User:Zxmlichao

Summary The statistical consulting experience in Lean & Six Sigma Organization at 3M helps me build up my professional goals. Years of experience in Merck global vaccine manufacturing makes me feel comfortable about all aspects of statistical support related to manufacturing. Since I have Biochemical Engineering, Chemical Engineering and Statistics background, the ideal role for me is to combine them all together. Working as a statistician and Lean & Six Sigma practitioner in industrial manufacturing could make use of all of my fortes.

Currently, I am a senior statistician at Novartis offering statistical support and training for Sandoz generic drug manufacturing.

Specialties: • Statistical Process Control (SPC) • Process Performance Qualification (PPQ) • Continuous Process Validation (CPV) • Annual Product Review (APR) • Design of Experiments(DOE) and Data Analysis • Process Modeling and Optimization • Data Mining and Process Characterization • Stability and Risk Analysis • Sampling Plan • Method Validation & Method Transfer • Quality by Design (QbD) • Statistical Training • Lean & Six Sigma Methodology Training and Application • Regulatory & Agency Compliance Experience SandozSenior Statistician Sandoz 2012 – Present (1 year)Raleigh-Durham, North Carolina Area Processes:

• Formulation • Granulation • Drying & Milling • Blending & Compression • Coating • Packaging

Stats Support:

• Raw Materials Sampling and Qualification • Process Performance Qualification (PPQ) • Continue Process Verification (CPV) • Stability & Risk Analysis • Quality by Design (QbD) • Lean & Six Sigma • Statistical Training and Coaching MerckProject/Process Statistician Merck 2008 – 2012 (4 years) •	Lead root causes investigations crossing all vaccine manufacturing with statistical skills and Lean & Six Sigma methodology. . •	Design of Experiments and data analysis for manufacturing research laboratories. •	Support stability data evaluation for release, shelf-life, and expiry requirements and report to agencies. •	Design and implement studies for Method Validation and Method Transfer. •	Response for protocol writing and report submission for agencies. (Open)1 project 3MProject Statistician 3M 2008 – 2008 (less than a year) Led root causes investigation for abrasive production process. Test method validation through abrasive manufacturing sites. Led root causes investigation for adhesive tape production process. Built demand forecasting models for filter market Project Manager Hamonia Consulting (China) Inc., Ltd 2002 – 2002 (less than a year) Provided technique support for the main consulting business of Harmonia: chemical & construction materials consulting. Responsible for the project of Applying Electrical Thermal Agitator to Production Line, which led to increased market share of $3M per year. Manager of International Business Department: Exported electrical and agriculture products to Europe and Australia. Project Leader Langfang Three-Well Chemical Industry Co. Ltd 1998 – 1999 (1 year) Led project team to successfully accomplish lab-scale and amplified scale for imidacloprid synthesis project. Invented a new six-step synthesis method for imidacloprid production, which broke through from the catalyst, temperature and solvent respectively. The new technology improved the production yield from 37% to 80%. Developed, instructed, guided imidacloprid synthesis project team to set up scale-up facility. Trained the technicians to operate and industrialize imidacloprid production with the new methods. Projects Bayesian Variance Components Estimation Using Half-Cauchy Priors in Mixed-Effect Models(Link) June 2012 – August 2012 Negative variance components, which should be non-negative by their definition and our common sense, are not rare in mixed effect models in real life. Statisticians have a hard time presenting convincing explanation of the result to others when meet this situation. Traditional methods like REML method can't really solve the problem by constraining the result. Moreover, forcing the negative...more 3 team members Richard Li Richard Li Senior Statistician at Sandoz Yi (Charlie) Chen Yi (Charlie) Chen Ph.D. (ABD) in Statistics at The University of Georgia No photo Chuck Miller Courses University of Tennessee-Knoxville - College of Business Administration Design of Experiment and Data Analysis Applied Linear Statistical Models Applied Multivariate Methods and Data Analysis Data Mining Statistics Inferences Introduction to Data Management and Directed Process Studies Statistical Methods University of Tennessee-Knoxville Advanced Chemical Engineering Thermodynamics Statistical Mechanics Introduction to Transport Phenomena Transport Phenomena II Chemical Reactor Analysis Process Modeling and Simulation Advanced Mathematics for Engineers Skills & Expertise Most endorsed for... 38Design of Experiments

20Statistics

19Validation

14Six Sigma

11Data Analysis

11SPC

9Quality by Design

9Data Mining

6Minitab

6SAS

Richard also knows about... 6Pharmaceutical Industry 5Lean Manufacturing 4JMP 3Statistical Modeling 2Chemical Engineering 2Pharmaceuticals 2Formulation 1Lean & Six Sigma 1Programming 1Continuous Process... 1Coatings 1R 1FDA Biochemical Engineering Process Optimization See 8+ Languages English Full professional proficiency Chinese Native or bilingual proficiency Education University of Tennessee-Knoxville - College of Business Administration Master, Satatistics 2007 – 2008 (Open)7 courses University of Tennessee-Knoxville University of Tennessee-Knoxville Master, Chemical Engineering 2003 – 2006 (Open)7 courses Tianjin University Bachelor, Biochemical Engineering 1994 – 1998 Additional Info Interests Sports, Music. Organizations Additional Organizations ASQ, ASA