User talk:110.225.82.136

Dopamine article minor correction
Dopamine article : Two statements contradict each other.

A. Functions Cellular effects .... the ultimate effect of D2-like activation (D2, D3, and D4) is usually inhibition of the target neuron ....

B. Disease, disorders, and pharmacology Psychosis and antipsychotic drugs .... typical antipsychotics worked as antagonists on the D2 receptors .... .... that in many cases of psychosis, including schizophrenia, three interconnected networks based on dopamine, serotonin, and glutamate - each on its own or in various combinations - contributed to an overexcitation of dopamine D2 receptors in the ventral striatum ....

A. says that dopamine activation of D2 has usually inhibitory effects B. says antipsychotics act as antagonist on D2 thus deactivating D2 and thus by statement A. leading to excitation effects or rather preventing inhibitory effects whereas the psychotic problem is usually excitation not inhibitory that is it requires as solution not excitation but inhibitory that is solution is to not prevent inhibitory effects but statement A. says D2 deactivation usually prevents inhibitory effects B. also says that in psychosis dopamine overexcites D2, thus saying that dopamine which activates D2 thus leads via D2 activation to excitation effects not inhibitory effects whereas statement A. says that D2 activation leads not to excitation effects but to inhibitory effects

I am not an expert but I think A. should say excitation not inhibitory. Thank you.

110.225.82.136 (talk) 09:09, 22 December 2020 (UTC)