User talk:173.73.235.172

I had a chronic exposure at home to Permethrin from an aerosol can of Raid Ant and Cockroach Killer that my husband sprayed indoors, and I am now showing signs of pre-motor Parkinson's disease. When I earlier had a MRI there was scarring of my brain, so there was lasting damage to my brain. I also had a painful case of trigeminal neuralgia. I have contacted SC Johnson, the EPA, the Maryland Department of Agriculture, and other organizations about this issue. I did not know it was one of the pesticides that caused Parkinson’s Disease or Parkinsonism when I was exposed - it wasn't listed in Wikipedia under Permethrin, in Wikipedia under Parkinson’s Disease, in a Scientific American article I read originally (Parkinson's Disease and Pesticides: What's the Connection? Scientists find a way chemicals may contribute to Parkinson’s from April 8, 2014), and in many other online sources. After searching, here are the studies that determined that Permethrin and some other synthetic pyrethroids are a significant risk factor for Parkinson’s Disease:

1. A 2006 publication noted this risk for Permethrin and Deltamethrin - Pyrethroid pesticide-induced alterations in dopamine transporter function. Elwan MA1, Richardson JR, Guillot TS,Caudle WM, Miller GW. Toxicol Appl Pharmacol. 2006 Mar 15;211(3):188-97. Epub 2005 Jul 11.(found at http://www.ncbi.nlm.nih.gov/pubmed/16005927) 2. A 2009 publication noted this risk for Permethrin and a few other pesticides  This publication concluded that the use of Permethrin was associated with more than a 3-fold increased risk of Parkinsonism. The publication is Occupation and Risk of Parkinsonism :  A Multicenter Case-Control Study  Caroline M. Tanner, MD, PhD; G. Webster Ross, MD; Sarah A. Jewell, MD, MPH; Robert A. Hauser, MD; Joseph Jankovic, MD; Stewart A. Factor, DO; Susan Bressman, MD; Amanda Deligtisch, MD; Connie Marras, MD, PhD, FRCPC; Kelly E. Lyons, PhD; Grace S. Bhudhikanok, PhD; Diana F. Roucoux, MPH; Cheryl Meng, MS; Robert D. Abbott, PhD; J. William Langston, MD. [+-] Author Affiliations Author Affiliations: Department of Clinical Research, The Parkinson's Institute, Sunnyvale, California (Drs Tanner, Jewell, Bhudhikanok, and Langston and Mss Roucoux and Meng); Department of Research and Development, Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii (Dr Ross); Department of Neurology, University of South Florida, Tampa, (Dr Hauser); Department of Neurology, Baylor College of Medicine, Houston, Texas (Dr Jankovic); Department of Neurology, Emory University School of Medicine, Atlanta, Georgia (Dr Factor); Department of Neurology, Beth Israel Medical Center, New York, New York (Drs Bressman and Deligtisch); Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada (Dr Marras); Department of Neurology, University of Kansas Medical Center, Kansas City (Dr Lyons); and Department of Statistics, University of Virginia School of Medicine, Charlottesville (Dr Abbott). Arch Neurol. 2009;66(9):1106-1113.doi: 10.1001/archneurol.2009.195.(found at http://www.ncbi.nlm.nih.gov/pubmed/19752299) 3. A 2012 publication noted this risk for the synthetic pyrethroid Cypermethrin, which is found in current consumer insecticide aerosols (including those for indoor use) -   A Current Review of Cypermethrin-Induced Neurotoxicity and Nigrostriatal Dopaminergic Neurodegeneration.Anand Kumar Singh,1,# Manindra Nath Tiwari,1,# Om Prakash,2 and Mahendra Pratap Singh1,* Curr Neuropharmacol. 2012 Mar; 10(1): 64–71. (found athttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286848/) 4. A 2014 publication noted this risk for Cyperemthrin - Cypermethrin alters the status of oxidative stress in the peripheral blood: relevance to Parkinsonism. Tripathi P1, Singh A, Agrawal S, Prakash O, Singh MP. Journal of Physiology and Biochemistry December 2014, Volume 70, Issue 4, pp 915-924. (found at http://www.ncbi.nlm.nih.gov/pubmed/25270427)

In addition, The National Parkinson Foundation has added Permethrin to its list of non-genetic risk factors for Parkinson's Disease (http://www.parkinson.org/understanding-parkinsons/what-is-parkinsons/Environmental-Factors-and-Parkinsons), as well as the Parkinson’s Disease Foundation  (http://www.pdf.org/environment_parkinsons_tanner).

Brendajskarp (talk) 02:00, 16 April 2016 (UTC)