User talk:2601:6C5:300:B230:1CD4:8875:C2CF:9887

"Like other kappa opioid antagonists currently under clinical investigation for the treatment of major depression, its efficacy may be compromised by the countervailing activation of pro-inflammatory cytokines in microglia within the CNS.[citation needed]

This is the citation: Missig G, Fritsch EL, Mehta N, Damon ME, Jarrell EM, Bartlett AA, Carroll FI, Carlezon WA Jr. Blockade of kappa-opioid receptors amplifies microglia-mediated inflammatory responses. Pharmacol Biochem Behav. 2022 Jan;212:173301. doi: 10.1016/j.pbb.2021.173301. Epub 2021 Nov 23. PMID: 34826432; PMCID: PMC8748402.

Note: Wikipedia will not advise me how to add citations. I tried to navigate it, but it was not intuitive.

If you or someone else can help me use it, I'd add it myself.