User talk:50.202.217.173/sandbox

Samei001 (talk) 15:52, 2 November 2018 (UTC)BERGMANN GLIOSIS  (to be added to astrocytosis)

Background:
- the generation of Bergmann astrocytes is referred to by Bergmann gliosis. The cell bodies of these astrocytes are found in the cerebellum within the Purkinjie cell layer of which the cell projections reach into the molecular layer (cite: Chapter 2 Basic Pathologic Reactions) - "Chaslin gliosis" indicates gliosis is found in the subpial areas. This is normally found in epilepsy. (cite: Chapter 2 Basic Pathologic Reactions) - Within the purkinjie cell layer, Bergmann glia (or bergmann astrocytes) can be found (cite: http://journals.sagepub.com/doi/pdf/10.1177/0192623310389621) - generation of bergmann astrocytes results in bergmann gliosis (cite: http://journals.sagepub.com/doi/pdf/10.1177/0192623310389621) - chemical toxicities are one of the many ways purkinjie cell death can occur, resulting in bergmann gliosis

How Bergmann gliosis (astrocytosis) occurs:
- due to Purkinjie cell death (cite: http://www.wikiwand.com/en/Bergmann_gliosis) - Purkinjie cell death is seen with ageing (Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers C. M. Greco R. J. Hagerman  F. Tassone  A. E. Chudley  M. R. Del Bigio  S. Jacquemont  M. Leehey P. J. Hagerman) - gliosis generally can be spotted via immunohistochemistry as well as PTAH which consist of special stains (cite: Chapter 2 Basic Pathologic Reactions)

Research analysis:
- immunochemical stainings can be used to view Bergmann gliosis. Anti-GFP antibodies reveal Bergmann gliosis (cite: neuronal intranuclear inclusionS)

Aftermath:
- cerebellar ataxia (due to purkinjie cell death/ lead to bergmann gliosis) (cite: Selective loss of Purkinje cells in a patient with anti-glutamic acid decarboxylase antibody-associated cerebellar ataxia)

AKA:
- radial epithelial cells -bergmann astrocytosis

BERGMANN GLIA