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In 1986, a Chinese scholar, Gao-De Li hypothesized that the 3D genome architecture might be linked to gene activities, cell differentiation and oncogenesis. Recently, more and more research evidence supports this hypothesis.

https://www.researchgate.net/publication/330688756_Abnormal_Chromatin_Configuration_and_Oncogenesis_in_Chinese https://doi.org/10.4236/oalib.1105185