User talk:A.S.M. Kamrul Huda MD, PhD (Japan)

A.S.M.Kamrul Huda MD,PhD. (Japan) Medical Science. Special Training on Neuromedicine. Kidney,Medicine and Liver Specialist. Chamber: Dalia Outdoor Service, Luxmipur, Rajshahi-6000, Bangladesh. Email:dhudamd@yahoo.com. Tell: +88-0721-760357.

Title: Aspirin 300mg controls IHD as a single medicine.

Letter to Editor: Ischaemic or ischemic heart disease (IHD), or myocardial ischaemia, is a disease characterized by reduced blood supply to the heart muscle, usually due to coronary artery disease (atherosclerosis of the coronary arteries). Its risk increases with age, smoking, hypercholesterolaemia (high cholesterol levels), diabetes, hypertension (high blood pressure) and is more common in men and those who have close relatives with ischaemic heart disease(1). Clinical manifestations of IHD are angina pectoris, Myocardial infraction, Heart failure, Arrhythmia, systemic hypertension and sudden death (2). IHD occor due to ischimia/reperfusion(I/R) injury in coronary arteries of heart. Varies pharmacological agent are use in IHD such as Nitrates: coronary vasodilators, β-blockers, pain killers, calcium chanel blocker, nifidipine and low dose of aspirin. Aspirin (USAN), also known as acetylsalicylic acid (pronounced, abbreviated ASA), is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, as an anti-inflammatory medication and anti-platelate effect (3). Anti-inflammatory effect of aspirin is reducing adhesion molecule, Interleukin-1 (IL-1) and prostaglandin synthesis(4). I prescribe aspirin 300mg to the patients of IHD, had chest tightness and/or pain. I carefully history each patients to excluding other gastrointestinal problem. Gastric acid protective drug did not reduce their chest pain. Excessive acid secration can cause IHD such as systemic hypertension like clinical manifestation. All patients were releive from syndromes that I know in the next visit.

A number of pro- and anti-inflammatory chemical combinded fight against I/R injury (5). Aspirin 75 mg is widely used with other pain killer in IHD patients because of having anti-inflammatory effect. I report for the first time that aspirin 300mg can be use as a single medicine in IHD patients to controlling clinical manifestation and releiving inflammatory pain both.

References:

1. Harisons Principles of internal medicine. 13th Edition. 2. QIMP-13. Dr. Ridwan Ullah Shahidi.

3. Clnical pharmacology, 8th edition, by D.R. Laurence, P.N. Bennett  & M.J. Brown.

4. An Essential Aid on Pharmacology, Fourth Edition, Edited by- Dr. M. Ruhul Kuddus Biplob. Rx Publication.

5. Carden DL, Granger DN, Pathophysiology of Ischemia/Reperfusion injury. J pathol, 2000 Feb; 190 (3): 255-66.