User talk:Amisten

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Adipose TAG lipase
Adipose triglyceride lipase (ATGL) is an enzyme that catalyzes the initial step in triglyceride hydrolysis in mammalian adipose tissue. ATGL contains a 'patatin domain' common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreased total adipose acyl-hydrolase activity.

Adipose triglyceride lipase (ATGL) is enlcoded by the human gene PNPLA2 (patatin-like phospholipase domain containing 2) (GeneID: 57104).

References

Zimmermann, R.; Strauss, J. G.; Haemmerle, G.; Schoiswohl, G.; Birner-Gruenberger, R.; Riederer, M.; Lass, A.; Neuberger, G.; Eisenhaber, F.; Hermetter, A.; Zechner, R. : Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science 306: 1383-1386, 2004. PubMed ID : 15550674