User talk:Ammardiwan

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RE: 5-HT(1A) Agonist
Heya. Well, as with modulating just about any molecular site in the brain, there will almost always be side effects. What is important is how marked those side effects are and whether the benefits outweigh them. If 5-HT1A receptor agonists are effective enough for depression and/or anxiety, I don't see a little cognitive/memory impairment getting in the way of them being successfully developed and marketed. After all, look at how successful benzodiazepines are in the psychopharmaceutical industry, despite the fact that they are quite good at inducing cognitive dysfunction. Since current serotonergic antidepressants and anxiolytics that act in part or full through 5-HT1A have not shown marked, if any, cognitive/memory deficit, I doubt it will be an issue, though the matter may differ with a high-affinity, selective full agonist. In any case, while selective 5-HT1A agonists have been found to be highly effective in treating depression in rodent models (e.g., eptapirone), so far human clinical trials have been disappointing in comparison and none have made it past phase III clinical trials (with the exception of a few azapirones like buspirone and tandospirone, but these are primarily used as anxiolytics and have poor efficacy for depression, at least by themselves). For that reason 5-HT1A has become a less-interesting target in recent times. The 5-HT4, 5-HT6, and 5-HT7 receptors are more intriguing in comparison, at least to me. I'm sure multi-action serotonergics like vilazodone and vortioxetine that combine 5-HT1A agonism with other properties such as serotonin reuptake inhibition will continue to be developed for some time however. Hope that helps! :) el3ctr0nika (Talk | Contribs) 23:29, 6 January 2012 (UTC)