User talk:Anernelson

Welcome
Everyone is welcome to contribute to Wikipedia. If you add material to an article and it is removed, a good place to start is on the discussion page for the article. Describe what you want to add and the verifiable references you want to cite in suppport of what is to be added. Articles about science and medicine usually have fairly high standards for references. If you feel that discussions are not getting you anywhere, please let me know. --JWSchmidt 03:34, 25 January 2006 (UTC)

WAS 4.250
You asked me:
 * 1) Who can post about Bird Flu? - answer:anyone
 * 2) Who can post on Avian Influenza? - answer:anyone
 * 3) Are there some restrictions? - answer:no
 * 4) The external link I have posted has now disappeared on 2 occasions. - answer:anyone can add, anyone can delete
 * 5) Now it sems like the whole topic has disappeared. - I moved it to a new heading.
 * 6) Looks like user WAS 4.250 moved only part of it to an influenza-virus-A topic instead. - I moved all that existed at the time of the move.
 * 7) What is the motivation and idea? - "Avian Flu" is a poorly conceived title. H5N1 is what most people mean. Influenzavirus A is the topic most the content was about. Influenza is the disease.
 * 8) Will the topic come back, including my link? - I really don't know what link was "yours". Add it and see what happens. If it is about the disease, add it to Influenza. Cheers. WAS 4.250 04:22, 25 January 2006 (UTC)

The suite of articles

 * Flu vaccine
 * The flu vaccine is a vaccine to protect against the highly variable influenza virus.


 * Influenza
 * Influenza (or as it is commonly known, the flu or the grippe) is a contagious disease of the upper airways and the lungs, caused by an RNA virus of the orthomyxoviridae family. It rapidly spreads around the world in seasonal epidemics, imposing considerable economic burden, in the form of health care costs and lost productivity. Three influenza pandemics in the 20th century, each following a major genetic change in the virus, killed millions of people.


 * Orthomyxoviridae
 * The Orthomyxoviridae are a family of RNA viruses which infect vertebrates. It includes those viruses which cause influenza.


 * Influenzavirus A
 * Influenzavirus A is a genus of the family of viruses called Orthomyxoviridae. Influenzavirus A has only one species in it; that species is called "influenza A virus". Influenza A virus causes "avian influenza" (also known as bird flu, avian flu, influenzavirus A flu, type A flu, or genus A flu). Variants are sometimes also labeled according to the species affected; such as "human flu" or "swine flu".


 * H5N1
 * H5N1 is an avian influenza virus. It is a pandemic threat. H5N1 flu is what is commonly meant when talking of "bird flu" or "avian influenza" and is a viral disease that causes illness in many species including humans.


 * Transmission and infection of H5N1
 * The transmission and infection of H5N1 is a concern due to the global spread of H5N1 that constitutes a pandemic threat. This article is about the transmission of the H5N1 virus, infection by that virus, the resulting symptoms of that infection (having or coming down with influenza or more specifically avian flu or even more specifically H5N1 flu which can include pneumonia), and the medical response including treatment.


 * Global spread of H5N1
 * The global spread of H5N1 (an avian virus) is a pandemic threat."Since 1997, studies of H5N1 indicate that these viruses continue to evolve, with changes in antigenicity and internal gene constellations; an expanded host range in avian species and the ability to infect felids; enhanced pathogenicity in experimentally infected mice and ferrets, in which they cause systemic infections; and increased environmental stability."


 * Influenza pandemic
 * An influenza pandemic is a large scale epidemic of the influenza virus, such as the 1918 Spanish flu. The World Health Organization (WHO) warns that there is a substantial risk of an influenza pandemic within the next few years. One of the strongest candidates is the A(H5N1) subtype of avian influenza. WAS 4.250 05:20, 25 January 2006 (UTC)

I copied our conversation to Talk:Influenzavirus A. Cheers. WAS 4.250 14:36, 25 January 2006 (UTC)

How H5N1 kills
H5N1 is a virus, not a poison. We have pictures of it reproducing. It has eight RNA molecules in each viron. We know the exact molecular makeup of hundreds of genotypes (varients) of both H5N1 and other avian flu viruses. For example, according to this genome database, the NS RNA molecule of one varient looks like this: gtgacaaaga cataatggat tccaacacga taacctcgtt tcaggtagat tgttatctat ggcacataag aaagctactc agtatgagag acatgtgtga tgcccccttt gatgacaggc tccgaagaga ccaaaaggca ttaaagggaa gaggcagcac acttggactc gatttaagag tggctacaat ggaggggaaa aagatcgttg aggacatcct gaagagtgag acaaatgaaa acctcaaaat agccattgct tccagtcctg ctcctcggta tatcaccgat atgagcatag aggagatgag ccgagaatgg tacatgctga tgcctaggca gaaaataact ggaggcctta tggtgaaaat ggaccaagcc ataatggata aaagaattat ccttaaagca aatttctcag ttctatttga tcaactagag acattagtct ctctgagggc attcacagaa agtggtgcta ttgtggctga aatatttccc attccctccg taccaggaca ttttacagag gatgtcaaaa atgcaattgg aatcctcatc ggtggacttg aatggaatga taactcaatt cgagcgtctg aaaatataca gagattcgct tggggaatcc atgatgagaa tgggggacct tcactccctc caaaacagaa acgctacatg gcgaaacgag ttgagtcaga agtttgaaga gatcagatgg ctcattgctg aatgtagaaa tatactgaca aagactgaaa atagctttga acagataaca tttttgcaag cattgcaact cttacttgaa gttgagagtg agataaggac cttctctttt cagcttattt aatactaaaa aacac

The NS RNA molecules codes for two proteins called NS1 and NEP. The NS1 protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast Asia are currently believed to be responsible for an enhanced proinflammatory cytokine response. H5N1 NS1 is characterized by a single amino acid change at position 92. By changing the amino acid from glutamic acid to aspartic acid, researchers were able to abrogate the effect of the H5N1 NS1. This single amino acid change in the NS1 gene greatly increased the pathogenicity of the H5N1 influenza virus.

In other words, we know down to the very atoms themselves what is (probably) going on. WAS 4.250 16:32, 27 January 2006 (UTC)

Links
Please do not add commercial links &mdash; or links to your own private websites &mdash; to Wikipedia. Wikipedia is not a vehicle for advertising or a mere collection of external links. See the welcome page if you would like to learn more about contributing to our encyclopedia. Thanks. -Will Beback 07:06, 28 January 2006 (UTC)